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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Semin Hematol. 2015 Jul 9;52(4):321–338. doi: 10.1053/j.seminhematol.2015.07.002

Figure 5.

Figure 5

GATA2 deficiency in the clinic: The patient presented as 18 year-old male with pancytopenia and marrow of AA, and within two years, he developed AML with myelodysplastic morphology.

A. Initial bone marrow biopsy at presentation: hypocellular marrow with trilineage hypoplasia compatible with AA. B-E. Bone marrow biopsy two years later: B. AML with myelodysplastic morphology; 30-40% cellularity. C. CD34 immunohistochemistry of biopsy, highlighting increased blasts. D. Dysplastic large osteoclast-like megakaryocyte with separated nuclear lobes, on aspirate smear. E. Pelgeroid PMN, peripheral smear. F. Small mononuclear megakaryocyte, on aspirate smear. G. Increased blasts, 35% on 500 cell differential of aspirate smear. (Courtesy of Dr. Danielle Townsley and Dr. Katherine Calvo).