Table 2.
Classification of bone marrow failure syndromes
| Acquired | Constitutional |
|---|---|
| Isolated anemia: PRCA | |
| Transient | Diamond-Blackfan anemia |
| • Transient aplastic crisis, parvovirus B19 | Inherited sideroblastic anemia |
| • Transient erythroblastopenia of childhood | Congenital dyserythropoietic anemia |
| Infection | |
| • Persistent parvovirus B19 infection (immunocompromised patients) | |
| • EBV, CMV, HIV, hepatitis viruses | |
| • Other infections | |
| Malignancies | |
| • Thymoma | |
| • LGL leukemia | |
| • CLL | |
| • Other hematologic and solid malignancies | |
| Drugs and chemicals | |
| Pregnancy | |
| Complication of major ABO-mismatch HSCT | |
| Erythropoietin antibody due to usage of recombinant human erythropoietin | |
| Idiopathic | |
| Bicytopenia / Pancytopenia | |
| Radiation | Fanconi anemia |
| Drugs and chemicals | Telomere diseases |
| • Cytotoxic drugs (chemotherapy) | • Dyskeratosis congenita |
| • Benzene | • Telomeropathies |
| Infections | GATA2 deficiency |
| • EBV | Schwachman-Diamond syndrome |
| • Hepatitis viruses | |
| • HIV | |
| • Parvovirus B19 | |
| Immune disease / Malignancies | |
| • LGL leukemia | |
| • Thymoma | |
| • PNH | |
| • Collagen vascular diseases | |
| Pregnancy | |
| Idiopathic | |