Table 5.
Estimates of 4-year decline in mean, 2-minute walking distance (meters) and 400-meter walk time (seconds)* in Health ABC participants by AF status at ages 70, 74, 78, and 82 years.
| Age 70 Est (95% CI) | Age 74 Est (95% CI) | Age 78 Est (95% CI) | Age 82 Est (95% CI) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Model | AF status | Walking distance (meters) | 400-meter walk time (seconds) | Walking distance (meters) | 400-meter walk time (seconds) | Walking distance (meters) | 400-meter walk time (seconds) | Walking distance (meters) | 400-meter walk time (seconds) |
| Model 1 | No prior AF | −1.20 (−2.32, −0.13) |
9.9 (7.24, 12.53) |
−6.20 (−6.81, −5.58) |
22.1 (20.5, 23.7) |
−11.16 (−11.9, −10.4) |
34.4 (32.3, 36.4) |
−16.13 (−17.5, −14.8) |
46.6 (43.2, 50.0) |
| With AF | −1.46 (−2.55, −0.36) |
10.5 (7.87, 13.19) |
−6.42 (−7.04, −5.81) |
22.8 (21.2, 24.3) |
−11.39 (−12.2, −10.6) |
35.0 (33.0, 37.0) |
−16.36 (−17.7, −15.0) |
47.2 (43.8, 50.6) |
|
| Difference† |
−0.23 (−0.39, −0.08)‡ |
0.7 (0.3, 1.0)§ |
−0.23 (−0.39, −0.08)‡ |
0.7 (0.3, 1.0)§ |
−0.23 (−0.39, −0.08)‡ |
0.7 (0.3, 1.0)§ |
−0.23 (−0.39, −0.08)‡ |
0.7 (0.3, 1.0)§ |
|
| Model 2 | No prior AF | −1.15 (−2.31, 0.02) |
9.7 (6.8, 12.5) |
−6.18 (−6.88, −5.47) |
22.1 (20.3, 23.9) |
−11.23 (−12.0, −10.4) |
34.5 (32.4, 36.6) |
−16.25 (−17.6, −14.9) |
46.9 (43.5, 50.4) |
| With AF | −1.36 (−2.53, −0.18) |
10.3 (7.4, 13.1) |
−6.39 (−7.09, −5.69) |
22.7 (20.9, 24.5) |
−11.44 (−12.2, −10.6) |
35.2 (33.0, 37.3) |
−16.46 (−17.8, −15.1) |
47.6 (44.1, 51.0) |
|
| Difference |
−0.21 (−0.37, −0.06)‡ |
0.6 (0.3, 1.0)§ |
−0.21 (−0.37, −0.06)‡ |
0.6 (0.3, 1.0)§ |
−0.21 (−0.37, −0.06)‡ |
0.6 (0.3, 1.0)§ |
−0.21 (−0.37, −0.06)‡ |
0.6 (0.3, 1.0)§ |
|
Est indicates estimate. Model 1 adjusted for baseline age, sex, race, site, and interaction of age*sex. Model 2, additionally adjusted for smoking, moderate/heavy drinking, baseline BMI, SBP, DBP, abnormal cholesterol, creatinine, and interactions of age with BMI and creatinine, and for hypertension, diabetes, cardiovascular disease, and cancer as time-varying covariates.
Walking distance in meters employed as a continuous measure.
Difference is the difference in 4-year walking distance decline between Health ABC participants with and without incident AF at the specified age.
P<0.01.
P<0.001.