Table 4.
Results from a whole-brain regression analysis and VAS data during the liraglutide fMRI session for the contrast of highly desirable vs less desirable food images in the fasting state
MNI coordinates (mm) | |||||||
---|---|---|---|---|---|---|---|
Cluster size (voxels) | Voxel z value | ||||||
x | y | z | Side | Identified region | General brain area | ||
Correlation with ‘How hungry do you feel right now?’ | |||||||
30 | 4.25 | 8 | −54 | 56 | C | Precuneus | Precuneus |
49 | 4.20 | −40 | −42 | 54 | L | Inferior parietal G | Parietal cortex |
70 | 4.05 | 24 | −58 | 56 | R | Precuneus | Precuneus |
Correlation with ‘How pleasant would it be to eat right now?’ | |||||||
214* | 5.03# | 14 | −76 | −8 | R | Occipital G | Occipital cortex |
3.98 | 12 | −80 | 0 | R | Cuneus | Cuneus | |
100 | 4.09 | −28 | −92 | 8 | L | Middle occipital G | Occipital cortex |
3.73 | −18 | −98 | 16 | L | Cuneus | Cuneus | |
46 | 3.86 | 24 | −84 | 26 | R | Precuneus | Precuneus |
71 | 3.83 | 6 | −86 | 18 | C | Cuneus | Cuneus |
30 | 3.66 | −14 | −56 | −2 | L | Occipital G | Occipital cortex |
3.33 | −14 | −64 | 2 | L | Cuneus | Cuneus | |
30 | 3.62 | 32 | −88 | 2 | R | Middle occipital G | Occipital cortex |
49 | 3.56 | −58 | −32 | −10 | L | Middle temporal G | Temporal lobe |
35 | 3.48 | −36 | −84 | 0 | L | Middle occipital G | Occipital cortex |
Correlation with ‘How much do you think you could eat right now?’ | |||||||
78 | 4.24 | 24 | −58 | 56 | R | Superior parietal lobule | Parietal cortex |
115 | 3.96 | −18 | −92 | 24 | L | Cuneus | Cuneus |
3.77 | −26 | −86 | 14 | L | Middle occipital G | Occipital cortex | |
55 | 3.64 | 6 | −92 | 20 | C | Cuneus | Cuneus |
Inverse correlation with ‘How nauseous do you feel right now?’ | |||||||
465* | 4.7 | 20 | −16 | 52 | R | Cingulate G | Cingulate cortex |
105 | 4.53 | −12 | −50 | 28 | L | Cingulate G | Cingulate cortex |
4.25 | −6 | −56 | 18 | C | Posterior cingulate G | Cingulate cortex | |
62 | 4.47 | 38 | −12 | 28 | R | Postcentral G | Somatosensory cortex |
98 | 4.05 | −50 | −38 | 4 | L | Superior temporal G | Temporal lobe |
3.84 | −36 | −30 | −2 | L | Hippocampus | Hippocampus | |
162* | 3.86 | 18 | −48 | 26 | R | Cingulate G | Cingulate cortex |
31 | 3.83 | 52 | −50 | 18 | R | Superior temporal G | Temporal lobe |
35 | 3.82 | 12 | −84 | 20 | R | Cuneus | Cuneus |
49 | 3.74 | −6 | −72 | 18 | C | Precuneus | Precuneus |
32 | 3.68 | 30 | −58 | 22 | R | Cuneus | Cuneus |
78 | 3.68 | −24 | −10 | 44 | L | Superior frontal G | Superior frontal |
3.29 | −30 | −8 | 52 | L | Precentral G | Sensorimotor |
Clusters which pass a threshold of p<0.001, uncorrected and have an extent of at least 20 voxels are shown. Peaks shown for clusters are the most significant along the same identified region
Statistical threshold: p<0.001, uncorrected; extent, 30 voxels
p<0.05, family-wise error corrected for cluster
†p<0.05, family-wise error corrected for peak
C, centre, G, gyrus; L, left; R, right; S, sulcus