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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Diabetologia. 2016 Feb 1;59(5):954–965. doi: 10.1007/s00125-016-3874-y

Table 4.

Results from a whole-brain regression analysis and VAS data during the liraglutide fMRI session for the contrast of highly desirable vs less desirable food images in the fasting state

MNI coordinates (mm)

Cluster size (voxels) Voxel z value

x y z Side Identified region General brain area
Correlation with ‘How hungry do you feel right now?’
30 4.25 8 −54 56 C Precuneus Precuneus
49 4.20 −40 −42 54 L Inferior parietal G Parietal cortex
70 4.05 24 −58 56 R Precuneus Precuneus

Correlation with ‘How pleasant would it be to eat right now?’
214* 5.03# 14 −76 −8 R Occipital G Occipital cortex
3.98 12 −80 0 R Cuneus Cuneus
100 4.09 −28 −92 8 L Middle occipital G Occipital cortex
3.73 −18 −98 16 L Cuneus Cuneus
46 3.86 24 −84 26 R Precuneus Precuneus
71 3.83 6 −86 18 C Cuneus Cuneus
30 3.66 −14 −56 −2 L Occipital G Occipital cortex
3.33 −14 −64 2 L Cuneus Cuneus
30 3.62 32 −88 2 R Middle occipital G Occipital cortex
49 3.56 −58 −32 −10 L Middle temporal G Temporal lobe
35 3.48 −36 −84 0 L Middle occipital G Occipital cortex

Correlation with ‘How much do you think you could eat right now?’
78 4.24 24 −58 56 R Superior parietal lobule Parietal cortex
115 3.96 −18 −92 24 L Cuneus Cuneus
3.77 −26 −86 14 L Middle occipital G Occipital cortex
55 3.64 6 −92 20 C Cuneus Cuneus

Inverse correlation with ‘How nauseous do you feel right now?’
465* 4.7 20 −16 52 R Cingulate G Cingulate cortex
105 4.53 −12 −50 28 L Cingulate G Cingulate cortex
4.25 −6 −56 18 C Posterior cingulate G Cingulate cortex
62 4.47 38 −12 28 R Postcentral G Somatosensory cortex
98 4.05 −50 −38 4 L Superior temporal G Temporal lobe
3.84 −36 −30 −2 L Hippocampus Hippocampus
162* 3.86 18 −48 26 R Cingulate G Cingulate cortex
31 3.83 52 −50 18 R Superior temporal G Temporal lobe
35 3.82 12 −84 20 R Cuneus Cuneus
49 3.74 −6 −72 18 C Precuneus Precuneus
32 3.68 30 −58 22 R Cuneus Cuneus
78 3.68 −24 −10 44 L Superior frontal G Superior frontal
3.29 −30 −8 52 L Precentral G Sensorimotor

Clusters which pass a threshold of p<0.001, uncorrected and have an extent of at least 20 voxels are shown. Peaks shown for clusters are the most significant along the same identified region

Statistical threshold: p<0.001, uncorrected; extent, 30 voxels

*

p<0.05, family-wise error corrected for cluster

p<0.05, family-wise error corrected for peak

C, centre, G, gyrus; L, left; R, right; S, sulcus