Figure - PMC

Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2017 Jun 1.

Published in final edited form as: Cell Signal. 2016 Feb 19;28(6):552–560. doi: 10.1016/j.cellsig.2016.02.010

Fig. 7 — Inosine dose-dependently induces hA_2AR-mediated cAMP production in cell-free membrane preparations.

CHO-hA_2AR cell membranes were incubated with indicated concentrations of CGS 21680 (CGS) and ZM 241385 (ZM) (A) and with inosine (B) in the presence and in the absence of the A_2AR-selective inverse agonist ZM 241385 for 30 min. Mean cAMP production ± SEM of representative experiments are shown (n=6; * and ***, p < 0.05 and p < 0.001 vs DMSO respectively; ## and ###, p < 0.001 and p < 0.001 vs inosine respectively).

Fig. 7 — Inosine dose-dependently induces hA_2AR-mediated cAMP production in cell-free membrane preparations.

CHO-hA_2AR cell membranes were incubated with indicated concentrations of CGS 21680 (CGS) and ZM 241385 (ZM) (A) and with inosine (B) in the presence and in the absence of the A_2AR-selective inverse agonist ZM 241385 for 30 min. Mean cAMP production ± SEM of representative experiments are shown (n=6; * and ***, p < 0.05 and p < 0.001 vs DMSO respectively; ## and ###, p < 0.001 and p < 0.001 vs inosine respectively).