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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Diabetologia. 2016 Feb 24;59(5):1021–1029. doi: 10.1007/s00125-016-3897-4

Fig. 3.

Fig. 3

Methylation of insulin genes in beta cells during diabetes progression in NOD mice. The methylation ratios for Ins1 (a) exon 2 and (b) intron 1–2 and of Ins2 (c) promoter, (d) exon 1, (e) exon 2 and (f) intron 1–2. Data were obtained from targeted high-throughput methylation sequencing of beta cell DNA pooled from 4–6 NOD mice of each age group. The average reads for each CpG site were 30,000–50,000