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. 2015 Dec 11;10(4):625–634. doi: 10.1016/j.molonc.2015.11.011

Figure 1.

Figure 1

Conditioned media from cells transduced with AAV2‐sTRAIL kills recipient U87 glioma cells when used in combination with lanatoside C. U87 cells were transduced with AAV‐GFP (control) or AAV‐sTRAIL, of which vector maps are shown in (A). Three days later, conditioned medium was transferred onto non‐transduced U87 cells. (B) U87 cells show insensitivity to the treatment with TRAIL protein or AAV‐sTRAIL medium alone, while a significant decrease in cell viability is observed when TRAIL protein or AAV‐sTRAIL is combined with lanatoside C, compared to AAV‐GFP control. (C) GBM8 cells neural spheres were found to be sensitive to the treatment with lanatoside C or AAV‐sTRAIL alone, but AAV‐sTRAIL combined with lanatoside C induced a significant decrease in cell viability, compared to AAV‐GFP control medium. Data presented as % cell viability in which the control group is set at 100% (*p < 0.05, **p < 0.01, ***p < 0.001).