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Left: the protein structure of GNAT1, derived from X-ray crystallographic measurements. The α-helical regions are coloured in pink, while β sheets are coloured in yellow. The six-stranded β-sheet domain, central to GTPase function, is fully formed. Right: the predicted structure of the truncated GNAT1 protein, showing the malformations in the fifth and sixth strands of the β-sheet domain.
