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. 2016 Mar;13(3):209–217. doi: 10.11909/j.issn.1671-5411.2016.03.007

Table 3. Unadjusted and propensity-score adjusted hazard ratios for 1-year endpoint in patients with PPIs versus no-PPIs within each P2Y12 receptor inhibitors (clopidogrel or ticagrelor).

Clopidogrel
Ticagrelor
P, Interaction of treatment with PPIs use, unadjusted/adjusted
Treated with PPIs (n = 4814) Not treated with PPIs (n = 4126) Unadjusted HR (95% CI) Adjusted HR (95% CI) Treated with PPIs (n = 351) Not treated with PPIs (n = 138) Unadjusted HR (95% CI) Adjusted HR (95% CI)
All-cause death/re-infarction bleeding 533/4814 (11.1%) 348/4126 (8.4%) 1.331 (1.161–1.524) 1.036 (0.903–1.189) 28/351 (8.0%) 5/138 (3.6%) 2.191 (0.846–5.674) 2.320 (0.875–6.151) 0.3100/0.2004
All-cause death/re-infarction 395/4814 (8.2%) 259/4126 (6.3%) 1.320 (1.129–1.544) 1.006 (0.858–1.181) 11/351 (3.1%) 1/138 (0.7%) 4.345 (0.561–33.658) 4.003 (0.502–31.932) 0.2534/0.2001
All-cause death 248/4814 (5.2%) 133/4126 (3.2%) 1.614 (1.307–1.992) 1.101 (0.889–1.364) 9/3519 (2.6%) 1/138 (0.7%) 3.536 (0.448–27.888) 3.199 (0.388–26.393) 0.4546/0.3608
Re-infarction 213/4814 (4.3%) 186/4126 (4.5%) 1.604 (1.299–1.980) 0.828 (0.677–1.012) 2/351 (0.6%) 0/138 (0.0%) - - 0.9679/0.9566
Bleeding 181/4814 (3.8%) 111/4126 (2.7%) 1.416 (1.118–1.794) 1.101 (0.865–1.401) 17/351 (4.8%) 5/138 (3.6%) 1.331 (0.491–3.607) 1.482 (0.533–4.117) 0.9028/0.9748

HR (unadjusted and adjusted) showing the relationship between PPIs and clinical outcomes. HR: hazard ratios; PPIs: proton pump inhibitors.