Table 1.
Metabolite control, renal and hepatic toxicological profile with dose of 5.0 μM MetfDeca.
| Metabolite | Control | Alloxan + 0.0 μM (MetfDeca) | Alloxan + 5.0 μM (MetfDeca) |
|---|---|---|---|
| Insulin (μU/mL) | 25.1 ± 5.2 | 3.4 ± 0.3▼ | 23.6 ± 3.6 |
| Glucose (mg/dL) | 122.4 ± 2.7 | 300 ± 13.7▲ | 129 ± 4.6 |
| Triglycerides (mg/dL) | 96.3 ± 5.1 | 55 ± 3.4▼ | 138 ± 9.6▲ |
| Cholesterol (mg/dL) | 62.1 ± 2.4 | 58 ± 1.8 | 65 ± 3.6 |
| Total bilirubin (mg/dL) | 0.7 ± 0.1 | 0.95 ± 0.1▲ | 0.51 ± 0.25 |
| AST (U/L) | 230 ± 16 | 316.5 ± 2.3▲ | 117.9 ± 3.1▼ |
| ALT (U/L) | 60 ± 1.65 | 86.4 ± 2.5▲ | 91.1 ± 1.2▲ |
| γGT (U/L) | 7.3 ± 0.75 | 14.6 ± 0.29▲ | 8.7 ± 0.21 |
| ALP (U/L) | 316 ± 23 | 620.9 ± 4.9▲ | 267.3 ± 8.1▼ |
| Sodium (mmol/L) | 144 ± 0.1 | 131.2 ± 0.5▼ | 137.5 ± 1.5▼ |
| Potassium (mmol/L) | 6.6 ± 0.1 | 4.91 ± 0.7▼ | 6.8 ± 0.4 |
| Urea | 36 ± 0.41 | 45 ± 3.6▲ | 67 ± 2.3▲ |
| Creatinine | 0.53 ± 0.01 | 0.96 ± 0.1▲ | 0.8 ± 0.09▲ |
The serum parameters are the average of 10 separate experimental animals ± SEM. ▲ indicates significant difference with values above the control group, while ▼ indicates significant difference with values below the control group with p ≤ 0.05 by Student's t-test. AST: aspartate transaminase, ALT: alanine aminotransferase, γGT: Gamma-glutamyl transpeptidase, and ALP: alkaline phosphatase.