Table 2.

Serum lipids in independent insulin model and insulin-requiring model with pharmacological treatments and MetfDeca.

Metabolite	NC (n = 20)	I-I (n = 20)	I-I + Metf (n = 20)	I-I + MetfDeca (n = 20)	I-R (n = 20)	I-R + insulin (n = 20)	I-R + MetfDeca (n = 20)
Total lipids (mg/dL)	176 ± 11	294 ± 20▲	190 ± 12↓	203 ± 20↓	546 ± 28▲	502 ± 21▲	223 ± 16▲↓
Triglycerides (mg/dL)	63.5 ± 5.0	135 ± 13▲	68 ± 6.2↓	108 ± 5▲	360 ± 10▲	340 ± 13▲	75 ± 3↓
Cholesterol (mg/dL)	89.5 ± 2.4	123 ± 14▲	110 ± 6.9▲	87 ± 3↓	173 ± 8▲	145 ± 18▲	135 ± 11▲↓
VLDL-C (mg/dL)	16.5 ± 1.8	21.2 ± 2.0▲	20 ± 1.5	23 ± 2▲	58.4 ± 2▲	29.1 ± 1.3▲↓	17 ± 2↓
LDL-C (mg/dL)	23 ± 2.6	65.1 ± 2.8▲	26.9 ± 2.5↓	24 ± 3↓	21 ± 1.8	31.4 ± 3▲	73 ± 5▲
HDL-C (mg/dL)	50 ± 6.5	36.7 ± 1.1▼	63.1 ± 3.2▲	40 ± 5	93.6 ± 11▲	84.5 ± 6▲	45 ± 2.4↓
FFA (mg/dL)	2.5 ± 0.6	5.5 ± 1.2▲	2.8 ± 0.4↓	2.3 ± 0.2↓	11.5 ± 1.2▲	3.2 ± 0.3↓	4.8 ± 0.8▲↓

The results shown are the average of 20 separate experimental animals ± SEM. ▲ indicates significant difference with values above the control group with normal calorie diet, ▼ indicates significant difference with values below the control group with normal calorie diet, while ↓ indicates significant difference with respect to groups I-I and I-R, p ≤ 0.05 one-way ANOVA test with Bonferroni post hoc test.