Table 1.
Baseline characteristics of patients according to the presence of cSVD.
| Variables | All patients n = 156 | CMBs (+) n = 57 | SLIs (+) n = 82 | WMHs (+) n = 95 |
|---|---|---|---|---|
| Age, y | 63.2 ± 9.1 | 65.1 ± 8.4∗ | 65.0 ± 8.7∗∗ | 64.7 ± 9.0∗ |
| Male, % | 107 (68.6) | 44 (77.2) | 60 (73.2) | 62 (65.3) |
| Hypertension, % | 104 (66.7) | 44 (77.2)∗ | 56 (68.3) | 70 (73.7)∗ |
| Diabetes mellitus, % | 37 (23.7) | 16 (28.1) | 22 (26.8) | 23 (24.2) |
| Dyslipidemia, % | 52 (33.3) | 15 (26.3) | 25 (30.5) | 30 (31.6) |
| Heart disease, % | 22 (14.1) | 8 (14.0) | 14 (17.1) | 13 (13.7) |
| BMI, kg/m2 | 25.1 (23.9–26.0) | 24.9 (24.0–25.9) | 25.3 (23.9–26.1) | 24.9 (23.9–25.8) |
| Smoking, % | 54 (34.6) | 19 (33.3) | 28 (34.1) | 35 (36.8) |
| Alcohol intake, % | 59 (37.8) | 22 (38.6) | 33 (40.2) | 38 (40.0) |
| SBP, mmHg | 140 (130–145) | 140 (131–149)∗ | 140 (130–148)∗ | 140 (130–148)∗ |
| DBP, mmHg | 85 (80–90) | 90 (80–95) | 85 (80–90) | 86 (80–90) |
| Antithrombotics use, % | 58 (37.2) | 18 (31.6) | 29 (35.4) | 37 (38.9) |
| Onset-to-MRI time, day | 2 (1-2) | 2 (1-2) | 2 (1-2) | 2 (1-2) |
| Onset-to-blood drawing time, day | 2 (1-2) | 2 (1-2) | 2 (1-2) | 2 (1-2) |
| NIHSS | 3 (2–5) | 3 (2–4.5) | 3 (2–5) | 3 (2–6) |
| Fasting glucose, mg/dL | 91.8 (85.1–105.6) | 92.2 (84.6–116.3) | 91.8 (84.6–104.8) | 93.6 (86.4–108.0) |
| Triglycerides, mg/dL | 119.0 (89.4–160.2) | 113.3 (87.2–149.1) | 107.1 (87.4–151.8) | 119.5 (87.6–159.3) |
| HDL, mg/dL | 40.8 ± 11.4 | 41.8 ± 12.9 | 41.1 ± 11.0 | 41.8 ± 11.7 |
| LDL, mg/dL | 95.0 ± 27.8 | 93.8 ± 22.2 | 94.1 ± 26.9 | 95.7 ± 24.3 |
| Total cholesterol, mg/dL | 157.2 ± 36.1 | 155.9 ± 30.5 | 155.6 ± 36.3 | 157.6 ± 34.9 |
| Fibrinogen, mg/dL | 296.1 ± 59.4 | 310.9 ± 61.1∗ | 301.2 ± 65.3 | 295.8 ± 58.1 |
| Cav-1, ng/mL | 5.62 ± 2.63 | 4.74 ± 2.26∗∗ | 5.71 ± 2.77 | 5.65 ± 2.58 |
CMBs, cerebral microbleeds; SLIs, silent lacunar infarcts; WMHs, white matter hyperintensities; BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; NIHSS, National Institutes of Health Stroke Scale; HDL, high-density lipoprotein; LDL, low-density lipoprotein; Cav-1, caveolin-1.
∗ P < 0.05; ∗∗ P < 0.01 compared with corresponding negative (−) group.