Fig. 1.

Time course of imaging responses. (A) Examples of individual responses as measured with PET (filled symbols) and MRI (open symbols). Square: oligoastrocytoma (#12); triangle: oligodendroglioma (#16); diamond: astrocytoma (#6). (B and C) Data points represent pooled volume changes measured for the whole cohort of metabolic responders during chemotherapy before progression (ie, participants were censored at the last PET or MRI prior to progression. Black lines correspond to exponential fit for PET data (B) (y = 74.61 * exp(−x/158.86) + 24.31) and linear fit for MRI data (C) (y = 99.27–0.05 * x), respectively. Values on the y-axis represent percent volume changes compared with baseline (ie, before the start of chemotherapy).