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. 2016 Apr 11;6:24125. doi: 10.1038/srep24125

Table 2. The metabolite variations between any two of the three brain regions at each time point (N = 6 each group).

Metabolite Types W7
 W9
 W12
 W24
 W56
 W111
C/H T/H T/C C/H T/H T/C C/H T/H T/C C/H T/H T/C C/H T/H T/C C/H T/H T/C
Lipids 0.90 0.99 1.10 1.06 1.02 0.96 0.97 1.04 1.07 1.08 0.99 0.92 0.92 0.97 1.06 0.91 0.98 0.98
 Glycerophospholipids 0.88 0.99 1.12 1.08 1.04 0.97 0.96 1.03 1.07 1.09 0.99 0.91 0.92 0.97 1.05 0.90 0.97 0.97
 Sphingolipids 0.99 1.01 1.01 1.04 1.01 0.97 1.11 1.10 0.99 0.99 0.99 1.00 0.91 0.96 1.05 0.96 0.98 0.98
Acylcarnitine 1.11 1.06 0.95 1.11 1.14 1.03 1.16 1.18 1.02 1.14 0.93 0.82 0.78*2 0.83 1.06 0.91 1.20 1.20*5
Free fatty acids 1.14 1.07 0.94 1.00 0.97 0.97 0.97 0.95 0.97 1.22 1.00 0.82 0.86 0.99 1.15 1.08 0.90 0.90
 Saturated fatty acids 1.12 1.05 0.93 0.99 0.95 0.95 0.95 0.93 0.97 1.16 0.99 0.85 0.84 0.97 1.15 1.04 0.89 0.89
 Monounsaturated fatty acids 1.12 1.03 0.92 1.00 1.00 1.00 0.94 0.99 1.06 1.31 0.96 0.74 0.91 1.04 1.15 1.13 0.89 0.89
 Polyunsaturated fatty acids 1.20 1.17 0.98 1.00 0.96 0.96 1.04 0.94 0.90 1.23 1.06 0.86 0.82 0.97 1.17 1.09 0.93 0.93
Bile acids 1.36 3.22 2.37 0.72 1.00 1.38 1.65 1.27 0.77 1.09 1.02 0.94 1.65 0.67 0.41 0.85 0.98 0.98
 Unconjugated bile acids 0.82 3.24 3.97 0.73 1.04 1.42 0.90 1.09 1.22 1.11 1.10 0.99 0.65 0.76 1.16 0.82 0.97 0.97
 Glycine conjugated bile acids 1.61 1.88 1.17 0.54 0.89 1.63 1.57 1.14 0.73 0.69 0.74 1.07 1.38 0.63 0.46 0.77 0.88 0.88
 Taurine conjugated bile acids 4.44 5.44 1.22 1.15 1.03 0.89 4.65 2.13 0.46 1.99 1.29 0.65 4.86 0.46 0.09 1.16 1.26 1.26
Amino acids 1.04 1.00 0.96 0.98 1.08 1.10 1.10 1.04 0.95 1.06 0.95 0.90 0.91 1.01 1.10 0.95 1.04 1.04
Organic acids 1.01 0.95 0.94 0.96 0.93 0.97 1.02 1.14 1.12 1.15 1.12 0.97 0.95 0.91 0.96 0.91 0.85 0.85
Carbohydrates 0.59 0.70 1.20 1.23 1.15 0.94 0.93 1.04 1.11 1.05 0.98 0.93 0.72 0.81 1.14 0.93 0.86 0.86
Amines 0.99 0.95 0.96 0.93 1.18 1.27 1.02 1.03 1.01 0.90 0.98 1.09 0.84*3 1.05 1.26*4 0.96 0.99 0.99
Indoles 1.53 1.10 0.72 0.67 1.42 2.12 0.95 0.62 0.65 0.88 0.74 0.85 1.13 1.29 1.14 1.39 1.19 1.19
Phenols 0.90 1.00 1.11 0.81 0.88 1.09 0.92 0.92 1.00 1.09 1.08 0.99 0.98 0.94 0.95 0.89 0.95 0.95
Steroids 1.05 0.75 0.71 1.11 0.84 0.76 0.96 1.02 1.06 1.14 1.25 1.10 1.02 1.11 1.09 0.95 1.25 1.25
Purines 0.92 1.05 1.15 1.14 0.89 0.78 1.03 1.11 1.08 1.01 1.03 1.02 0.81 0.82 1.01 1.15 1.10 1.10
Pyridines 1.13 0.93 0.82 0.86 1.09 1.26 1.02 0.81 0.79 0.91 0.80 0.88 1.04 1.22 1.17 1.07 1.05 1.05
Peptides 0.63*1 0.95 1.50 0.92 1.25 1.36 0.73 0.76 1.05 0.77 0.67 0.88 1.24 0.91 0.74 1.02 1.36 1.36
Others 0.99 1.02 1.03 1.01 1.04 1.02 0.99 1.03 1.05 0.98 0.98 1.00 0.90 0.81 0.90 1.09 0.95 0.95

C indicates cortex; H indicates hippocampus; T indicates thalamus.

*1indicates P = 0.025, *2indicates P = 0.025, *3indicates P = 0.010, *4indicates P = 0.037, and *5indicates P = 0.036 in Mann Whitney test.