Table 1.
Genome-wide Significant Signals of Selection in GERA Data
| Locus | Chromosome | Region (Mb) | PC | Best Hit | p Value |
|---|---|---|---|---|---|
| LCT9 | 2 | 134.8–137.6 | 1 | rs6754311 | 4.15 × 10−27 |
| 3 | rs4988235 | 1.83 × 10−29 | |||
| ADH1B | 4 | 100.5 | 1 | rs1229984 | 1.67 × 10−14 |
| IRF474, 75 | 6 | 0.3–0.5 | 3 | rs12203592 | 8.69 × 10−22 |
| 4 | 1.83 × 10−56 | ||||
| HLA72 | 6 | 30.8–33.3 | 1 | rs382259 | 7.95 × 10−14 |
| 3 | rs9268628 | 6.52 × 10−19 | |||
| 4 | rs34707463 | 4.76 × 10−12 | |||
| IGFBP3 | 7 | 45.3–45.9 | 2 | rs150353309 | 3.14 × 10−12 |
| Chr8 Inversion42 | 8 | 8.2–11.9 | 4 | rs6984496 | 9.21 × 10−13 |
| IGH | 14 | 106.0–106.1 | 2 | rs34614900 | 3.34 × 10−9 |
| OCA273, 75 | 15 | 25.9–26.2 | 1 | rs12916300 | 1.12 × 10−8 |
| 2 | 3.07 × 10−9 | ||||
| 3 | 4.29 × 10−14 |
We list regions with genome-wide significant (α = 0.05, Bonferroni correction with 608,981 SNPs × 4 PCs = 2,435,924 hypotheses tested, p < 2.05 × 10−8) evidence of selection in the top four PCs. We provide previous reference(s) where available. The chromosome 8 inversion signal is due to a PC artifact (see Results). Regions with suggestive evidence of selection (10−6 < p < 2.05 × 10−8) are listed in Table S3.