Table 1. LND Cases and Controls Used in the Autopsy Study.
| Case | Age at Death, yr | PMI, h | Additional Diagnoses | Cause of Death | Findings |
|---|---|---|---|---|---|
| LND1 | 5 | 8 | Renal insufficiency | Respiratory arrest | Mild gliosis and pigmentary incontinence in SN |
| LND2 | 11 | 50 | Pneumonia, nephrolithiasis | Cardiorespiratory arrest | Ubiquitin + cytoplasmic staining and inclusions in SN |
| LND3 | 21 | <2 | None | Accidental asphyxiation | Mild gliosis and pigmentary incontinence in SN |
| LND4 | 31 | 24 | Candida sepsis, asthma | Respiratory failure | Candida infection; subacute contusion in cortex; diffuse superficial spongiosis |
| LND5 | 34 | <4 | Chronic respiratory distress | Seizure with aspiration | Vascular proliferation |
| CON1 | 5 | 17 | None | Cardiac arrest | No significant pathology |
| CON2 | 12 | 18 | Clotting disorder | Stroke | No significant pathology |
| CON3 | 40 | 31 | Pancreatitis | Peritonitis and sepsis | No significant pathology |
| CON4 | 45 | 28 | Metastatic colon cancer | Metastatic colon cancer | No significant pathology |
| CON5 | 70 | 24 | Cardiovascular disease | Myocardial infarction | No significant pathology |
| CON6 | 92 | <12 | Parkinson disease | N/A | No significant pathology |
Data are given for 5 Lesch–Nyhan disease (LND) cases (LND1–LND5) and for 6 controls (CON1–CON6).
N/A = not available; PMI = postmortem interval; SN = substantia nigra.