Table 1.
Comparisons of the clinical features between the MN and BN groups
| Total patients (n = 194) |
BN group (n = 107) |
MN group (n = 87) |
P | |
|---|---|---|---|---|
| At time of biopsy | ||||
| Sex (male:female) | 160:34 | 81:26 | 79:8 | 0.006 |
| Age (y) | 43.8 ± 4.1 | 47.4 ± 10.3 | 39.4 ± 10.7 | <0.001 |
| Hypertension family history | 114(58.8 %) | 59(55.1 %) | 55(63.2 %) | 0.26 |
| Hypertension duration (y) | 5.0(1.0-9.0) | 6.0(2.4-10.0) | 3.0(0.2-7.0) | <0.001 |
| SBP (mmHg) | 195 ± 37 | 182 ± 32 | 213 ± 32 | <0.001 |
| DBP (mmHg) | 126 ± 26 | 119 ± 23 | 138 ± 25 | <0.001 |
| MAP (mmHg) | 150 ± 27 | 139 ± 24 | 163 ± 25 | <0.001 |
| Current smoker | 57(29.4 %) | 30(28.0 %) | 27(31.0 %) | 0.65 |
| Grades of retinopathy | ||||
| I-II (%) (n*) | 73(50.3 %)(145) | 44(58.7 %)(75) | 29(41.4 %)(70) | <0.001 |
| III-IV (%) (n*) | 42(29.0 %)(145) | 8(10.7 %)(75) | 34(48.6 %)(70) | |
| Hypertensive heart disease | 110(56.7 %) | 42(39.3 %) | 68(78.2 %) | <0.001 |
| Hypertensive cerebrovascular disease | 18(9.3 %) | 12(11.2 %) | 6(6.9 %) | 0.30 |
| Scr (mg/dl) | 1.61(1.24-2.27) | 1.35(1.07-1.60) | 2.27(1.74-3.14) | <0.001 |
| eGFR (ml/min/1.73 m2) | 49.6(32.8-65.7) | 60.5(48.9-76.5) | 34.5(24.2-46.8) | <0.001 |
| eGFR < 60 ml/min/1.73 m2 | 130(67.0 %) | 51(47.7 %) | 79(90.8 %) | <0.001 |
| Uric acid (μmol/l) | 455 ± 109 | 437 ± 111 | 482 ± 101 | 0.004 |
| Anemia | 36(18.6 %) | 10(9.3 %) | 26(29.9 %) | <0.001 |
| Elevated LDH | 5(2.6 %) | 0(0 %) | 5(5.7 %) | - |
| Thrombocytopenia | 1(0.5 %) | 0(0 %) | 1(1.1 %) | - |
| Proteinuria (g/24 h) | 0.80(0.42-1.48) | 0.72(0.38-1.34) | 0.89(0.58-1.57) | 0.02 |
| Microscopic hematuria | 46(23.7 %) | 31(29.0 %) | 15(17.2 %) | 0.06 |
| Follow-up | ||||
| No. of antihypertensive drugs | 2.7 ± 1.3 | 2.3 ± 1.1 | 3.3 ± 1.2 | <0.001 |
| Time-average MAP (mmHg) (n*) | 129 ± 13(157) | 124 ± 11(88) | 135 ± 14(69) | <0.001 |
| ESRD | 36(18.6 %) | 7(6.5 %) | 29(33.3 %) | <0.001 |
Data are presented as the medians (25th and 75th percentiles), the mean ± SD, or the number of positive cases (percentages). n* is the available n for a given value. Where not specified, the available n is the same as the total number of cases in the top row
BN, benign nephrosclerosis; MN, malignant nephrosclerosis; SBP, systolic blood pressure; DBP, diastolic blood pressure; MAP, mean blood pressure; Scr, serum creatinine; eGFR, estimated glomerular filtration rate; LDH, lactate dehydrogenase; ESRD, end-stage renal disease