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. 2016 Apr 11;11:17. doi: 10.1186/s13020-016-0089-6

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© Kim et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Effect of SHINBARO on the bone morphometric parameters in MIA-induced OA rat model. The bone morphometric parameters including BV (a), BV/TV (b), and Obj.N (c) were analyzed with micro-CT SkyScan CTAN software. Data represent the mean ± SD (n = 6). *P < 0.05 and **P < 0.01 indicate statistically significant differences from the vehicle-treated MIA group. ^## P < 0.01 indicates statistically significant differences from the control group. C control group, V vehicle-treated MIA group, IAS intra-articular SHINBARO group, OS oral SHINBARO group, P positive control group (Diclofenac 5 mg/kg)