Fig. 6.

Effect of SHINBARO on the protein levels of NF-κB, IκB-α, TNF-α and IL-1β in cartilage from the knee joint after treatment of SHINBARO in MIA-induced OA rat model. The expressions of NF-κB, IκB-α, TNF-α and IL-1β in the extracted cartilage tissues were determined by Western blot analysis as described in the “Methods” section. Data were representative of three separate experiments. β-actin was used as an internal standard. C control group, V vehicle-treated MIA group, IAS intra-articular SHINBARO group, OS oral SHINBARO group, P positive control group (Diclofenac 5 mg/kg)