Table 2. Differentially Methylated Regions in the Twin With an Alcohol Use Disorder Compared With the Unaffected Twin.

Gene (Nimblegen Identification Number)	Gene Symbol	pfpa	Location	CpGb Context
Top hypermethylated regions (p<1×10−5)
Protein phosphatase 1G (CHR02P027457864)	PPM1G	<1×10−5	Body	Shore
Insulin- insulin-like growth factor 2 (CHR11P002137905)	INS_IGF2	<1×10−5	Body	Shelf
NA (CHR05P064022468)	NA	3×10−4	Intergenic	Island
Nucleosome assembly protein 1-like 2 (CHRXP072351512)	NAP1L2	3×10−3	Body	Open sea
Solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 (CHR05P001469753)	SLC6A3	4×10−3	Body	Shore
Hypothetical protein LOC149840 (CHR20P005679048)	NA	4×10−3	Body	Open sea
Ubiquitin-conjugating enzyme E2M pseudogene 1 (CHR16P034261914)	UBE2MP1	6×10−3	Body	Shore
Absent in melanoma 1 (CHR06P107065946)	AIM1	7×10−3	Body	Shore
NA (CHR09P069075112)	NA	7×10−3	Intergenic	Island
Opioid receptor-like 1 (CHR20P062188944)	OPRL1	7×10−3	Body	Island
Top hypomethylated regions (p<1×10−5)
Neurotrophic tyrosine kinase, receptor, type 1 (CHR01P155095309)	NTRK1	>1×10−5	Body	Shore
NA (CHR02P095678989)	NA	>1×10−5	Intergenic	Shore
Formin 1 (CHR15P031274371)	FMN1	>1×10−5	Body	Island
Selenophosphate synthetase 2 (CHR16P030364503)	SEPHS2	>1×10−5	Body	Island
Myocyte enhancer factor 2D (CHR01P154736441)	MEF2D	3×10−4	Body	Island
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (CHR10P006245627)	PFKFB3	3×10−4	Body	Island
Solute carrier family 45, member 4 (CHR08P142298123)	SLC45A4	4×10−4	Body	Island
L-pipecolic acid oxidase (CHR17P024393350)	PIPOX	4×10−4	Body	Open sea
Fibroblast growth factor (acidic) intracellular binding protein (CHR11P065412364)	FIBP	2×10−3	Body	Island
MIRLET7B host gene (nonprotein coding) (CHR22P044859950)	MIRLET7BHG	2×10−3	Body	Open sea

^apfp=percentage of false positives.

^bCpG=cytosine-guanine dinucleotide.