Appendix 1.
Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations and Ovid MEDLINE(R) 1946 to Present
| # | Searches | Results | Search type |
|---|---|---|---|
| 1 | Hypothyroidism/or hypothyroidism.mp. | 34,300 | Advanced |
| 2 | Thyroxine/ad, tu [Administration & Dosage, Therapeutic Use] | 6409 | Advanced |
| 3 | ((l adj thyroxin*) or levothyroxine).mp. or 2 [mp = title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier] | 9424 | Advanced |
| 4 | thyroxine.mp. and hormone replacement therapy/ [mp = title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier] | 516 | Advanced |
| 5 | or/2–3 | 9424 | Advanced |
| 6 | 1 and 5 | 4670 | Advanced |
| 7 | exp Pregnancy Complications/ or Pregnancy Trimesters/ or pregnancy.mp. or Pregnancy Maintenance/ or exp Pregnancy/ or Pregnancy Rate/ or Pregnancy Trimester, Second/ or Pregnancy Outcome/ or Pregnancy Trimester, Third/ or Pregnancy Trimester, First/ | 804,495 | Advanced |
| 8 | (pregnancy or pregnant or preterm or gestational or apgar or intrauterine or birth or prematur*).mp. [mp = title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier] | 1,046,192 | Advanced |
| 9 | abortion, spontaneous/ or premature birth/ or obstetric labor, premature/ or diabetes, gestational/ or stillbirth.mp. [mp = title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier] | 42,777 | Advanced |
| 10 | fetal growth retardation/ or infant, low birth weight/ or infant, very low birth weight/ or infant, extremely low birth weight/ or infant, small for gestational age/ | 37,380 | Advanced |
| 11 | hypertension, pregnancy induced/ or hellp syndrome/ or eclampsia/ or abruptio placentiae/ or pre-eclampsia/ or apgar score/ | 34,310 | Advanced |
| 12 | pregnancy outcome/ or miscarriage/ or fetal membranes, premature rupture/ or placenta previa/ | 55,760 | Advanced |
| 13 | Cesarean Section/ | 35,016 | Advanced |
| 14 | cesarean*.mp. or 9 or 10 or 11 or 12 or 13 [mp = title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier] | 172,657 | Advanced |
| 15 | or/7–8,14 | 1,082,749 | Advanced |
| 16 | 6 and 15 | 701 | Advanced |
| 17 | limit 16 to (clinical trial, all or clinical trial, phase i or clinical trial, phase ii or clinical trial, phase iii or clinical trial, phase iv or clinical trial or comparative study or controlled clinical trial or evaluation studies or meta analysis or multicenter study or observational study or randomized controlled trial) | 73 | Advanced |
| 18 | 16 and (followup.mp. or follow-up studies/ or cohort*.mp. or prospective*.mp. or retrospective*.mp. or “cross-section*”.mp. or trial*.mp. or meta-analysis.mp.) [mp = title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier] | 180 | Advanced |
| 19 | 17 or 18 | 203 | |
| Cochrane—same strategy, 21 | |||
| Embase 1988 to 2015 Week 04 | |||
| 1 | hypothyroidism/ or subclinical hypothyroidism/ | 31,682 | Advanced |
| 2 | thyroxine/ct, ad, dt | 5402 | Advanced |
| 3 | (l adj thyroxine*).mp. [mp = title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer, device trade name, keyword] | 2127 | Advanced |
| 4 | levothyroxine sodium/ or levothyroxine/ | 12,441 | Advanced |
| 5 | or/2–4 | 18,035 | Advanced |
| 6 | 1 and 5 | 7932 | Advanced |
| 7 | exp pregnancy/ or exp pregnancy complications/ | 377,906 | Advanced |
| 8 | spontaneous abortion/ | 22,634 | Advanced |
| 9 | exp labor complication/ | 106,863 | Advanced |
| 10 | exp pregnancy disorder/ | 312,598 | Advanced |
| 11 | intrauterine growth retardation/ | 16,924 | Advanced |
| 12 | exp low birth weight/ | 37,013 | Advanced |
| 13 | exp “eclampsia and preeclampsia”/ | 33,153 | Advanced |
| 14 | exp “parameters concerning the fetus, newborn and pregnancy”/ | 213,446 | Advanced |
| 15 | or/7–14 | 598,381 | Advanced |
| 16 | 6 and 15 | 976 | Advanced |
| 17 | exp evidence-based medicine/ | 687,624 | Advanced |
| 18 | exp cross-sectional study/ or exp incidence/ or exp seasonal variation/ | 420,077 | Advanced |
| 19 | follow up/ | 829,505 | Advanced |
| 20 | exp cohort analysis/ or exp correlational study/ or exp cross-sectional study/ or exp double blind procedure/ | 428,223 | Advanced |
| 21 | prospective study/ or retrospective study/ | 618,004 | Advanced |
| 22 | exp case control study/ or exp case study/ or exp clinical trial/ or exp “clinical trial (topic)”/ or exp longitudinal study/ or exp major clinical study/ or exp prospective study/ or exp retrospective study/ | 2,996,565 | Advanced |
| 23 | or/17–22 | 3,909,344 | Advanced |
| 24 | 16 and 23 | 321 | Advanced |
| 25 | limit 24 to human | 316 | Advanced |
| 26 | 25 not case report/ | 265 | Advanced |
WoS
TOPIC: (hypothyroid* AND (pregnan* OR trimester* OR birth OR gestation* OR abortion OR obstetric* OR prematur* OR fetus OR fetal OR foetus OR foetal OR preeclampsia OR “pre-eclampsia” OR hellp)) AND TOPIC: (levothyroxin* OR lt4 OR “l t4” OR thyroxin*) AND TOPIC: (outcome* OR trial* OR study OR studies OR series OR follow* or cohort* or prospective* OR retrospective* OR meta-analysis) AND TOPIC: (subclinical* OR “sub clinical*” OR asymptomatic* OR silent OR covert OR screen*) 396
Scopus
( TITLE-ABS-KEY ( : ( hypothyroid* AND ( pregnan* OR trimester* OR birth OR gestation* OR abortion OR obstetric* OR prematur* OR fetus OR fetal OR foetus OR foetal OR preeclampsia OR ”pre-eclampsia” OR hellp ) ) ) AND TITLE-ABS-KEY( ( levothyroxin* OR lt4 OR ”l t4” OR thyroxin* ) ) AND TITLE-ABS-KEY ( ( outcome* OR trial* OR study OR studies OR series OR follow* OR cohort* OR prospective* OR retrospective* OR meta-analysis ) ) AND TITLE-ABS-KEY ( ( subclinical* OR ”sub clinical*” OR asymptomatic* OR silent OR covert OR screen* ) ) AND NOT TITLE-ABS-KEY ( rats OR rat OR mice OR mouse OR rodent* ) ) AND ( LIMIT-TO ( DOCTYPE, ”ar” ) OR LIMIT-TO ( DOCTYPE, ”re” ) OR LIMIT-TO ( DOCTYPE, ”cp” ) 799