Table 2.

Multivariate Analysis of Individual Molecular Marker with Postoperative Clinicopathologic Variables in Prophylactic PTCs (n = 237)

Statistic of molecular marker			Significance of clinicopathologic factors (p-value only)
Molecular marker	RR	CI	p-Value	Sex	Age (≥45 years)	Size (>2 cm)	Multifocality	LVI	ETE	Margins	FVPTC	TCVPTC
BRAFV600E	1.55	0.99–2.41	0.05	0.72	0.25	0.29	0.83	0.71	0.05	<0.01*	<0.01*	0.48
miR-21	1.00	0.90–1.12	1.00	0.74	0.53	0.28	0.31	0.82	0.02*	<0.01*	<0.01*	0.36
miR-146-3p	1.09	1.01–1.18	0.03*	0.41	0.27	0.17	0.69	0.79	0.06	<0.01*	<0.01*	0.21
miR-146-5p	1.12	1.02–1.24	0.02*	0.54	0.15	0.20	0.79	0.75	0.02*	<0.01*	<0.01*	0.44
miR-204	0.99	0.91–1.07	0.74	0.87	0.26	0.23	0.40	0.49	0.07	<0.01*	<0.01*	0.23
miR-221	1.05	0.97–1.14	0.20	0.72	0.17	0.27	0.33	0.67	0.03*	<0.01*	<0.01*	0.36
miR-222	1.11	0.99–1.25	0.08	0.90	0.23	0.22	0.49	0.51	0.04*	<0.01*	<0.01*	0.43
miR-375	1.04	0.98–1.10	0.22	0.90	0.33	0.11	0.51	0.98	0.05	<0.01*	<0.01*	0.22

Formula: CLNM = molecular marker + sex + age (>45 years) + size (>2 cm) + FVPTC + TCVPTC + multifocality + LVI + ETE + involvement of margins.

Each row represents an independent postoperative predictor model performed for CLNM. In the prophylactic cohort, independent predictors for CLNM were miR-146b-3p, miR-146b −5p multifocality, LVI, and ETE.

^*Statistically significant.

CI, confidence interval; CLNM, central lymph node metastasis; ETE, extrathyroidal extension; FVPT, follicular variance of PTC; LVI, lymphovascular invasion; PTC, papillary thyroid cancer; RR, relative risk; TCVPTC, tall-cell variance of PTC.