Table 3.

Multivariate Analysis of Individual Molecular Marker with Preoperative Clinicopathologic Variables in Prophylactic PTCs (n = 237)

Statistic of molecular marker				Clinicopathologic factors (p-value only)
Molecular marker	RR	CI	p-Value	Sex	Age (≥45 years)	Size (>2 cm)
BRAFV600E	1.69	1.11–2.57	0.01*	0.52	0.85	0.01*
miR-21	1.04	0.92–1.16	0.56	0.67	0.72	0.01*
miR-146-3p	1.10	1.02–1.19	0.01*	0.96	0.98	0.01*
miR-146-5p	1.15	1.04–1.26	0.01*	0.75	0.69	0.01*
miR-204	0.96	0.88–1.04	0.30	0.54	0.80	0.01*
miR-221	1.07	0.99–1.16	0.07	0.66	0.64	0.01*
miR-222	1.16	1.03–1.30	0.01*	0.47	0.76	0.01*
miR-375	1.05	0.98–1.11	0.15	0.51	0.87	<0.01*

Each row represents an independent preoperative predictor model performed for CLNM. In the prophylactic cohort, independent preoperative predictors for CLNM were BRAF^V600E mutation, miR-146b-3p, miR-146-5p, miR-222, and tumor size.

^*Statistically significant.