Table 5.

Multivariate Analysis of Individual Molecular Marker with Preoperative Clinicopathologic Variables in Prophylactic CVPTCs (n = 192)

Statistic of molecular marker				Clinicopathologic factors (p-value only)
Molecular marker	RR	CI	p-Value	Sex	Age (≥45 years)	Size (>2 cm)
BRAFV600E	1.50	0.93–2.40	0.09	0.32	0.61	0.02*
miR-21	1.02	0.90–1.15	0.80	0.42	0.95	0.01*
miR-146-3p	1.09	1.00–1.19	0.06	0.69	0.70	0.01*
miR-146-5p	1.17	1.05–1.32	0.01*	0.56	0.41	0.02*
miR-204	0.92	0.84–1.01	0.08	0.42	0.61	0.04*
miR-221	1.10	1.01–1.19	0.03*	0.44	0.36	0.03*
miR-222	1.20	1.06–1.36	0.00*	0.28	0.50	0.02*
miR-375	1.06	0.99–1.14	0.09	0.33	0.76	<0.01*

Formula: CLNM = molecular marker + sex + age (>45 years) + size (>2 cm).

Each row represents an independent preoperative predictor model performed for CLNM. In the CVPTC prophylactic subgroup, independent preoperative predictors for CLNM were miR-146-5p, miR-221, miR-222, and tumor size.

^*Statistically significant.