Table 3.

The association between serum 25-hydroxyvitamin D ¹ and total glioma by sex and age of case at diagnosis

	Odds Ratios and 95 % Confidence Intervals					PTrend3
	Quintiles of serum 25(OH) D2
	1	2	3	4	5
Quintile (nmol/L)	≤42.2	42.2–54.1	54.1–65.5	65.5–79.7	≥79.7
Glioma (Men)
Cases/Controls	41/93	40/85	42/72	44/84	43/68
≤ 56 years old, OR4 (95% CI)5	1.00	1.20 (0.68, 2.10)	1.45 (0.83, 2.52)	1.31 (0.74, 2.32)	1.55 (0.86, 2.82)	0.15
Cases/Controls	27/45	41/61	39/75	40/76	38/86
> 56 years old, OR (95% CI)	1.00	1.09 (0.57, 2.07)	0.80 (0.42, 1.50)	0.81 (0.43, 1.53)	0.66 (0.33, 1.31)	0.09
Cases/Controls	68/138	81/146	81/148	84/160	81/154
Total	1.00	1.15 (0.76, 1.75)	1.12 (0.74, 1.70)	1.08 (0.71, 1.64)	1.07 (0.68, 1.66)	0.99
Glioma (Women)
Cases/Controls	21/50	25/38	15/34	20/33	18/35
≤ 56 years old, OR (95% CI)	1.00	1.57 (0.77, 3.19)	1.06 (0.48, 2.34)	1.29 (0.60, 2.78)	1.26 (0.57, 2.83)	0.71
Cases/Controls	22/34	13/37	24/42	22/29	17/34
> 56 years old, OR (95% CI)	1.00	0.57 (0.25, 1.28)	0.95 (0.47, 1.93)	1.27 (0.59, 2.74)	0.76 (0.33, 1.77)	0.88
Cases/Controls	43/84	38/75	39/76	42/62	35/69
Total	1.00	0.97 (0.58, 1.64)	1.00 (0.59, 1.68)	1.28 (0.75, 2.20)	0.98 (0.56, 1.74)	0.72
Total Glioma
Cases/Controls	62/143	65/123	57/107	64/117	61/103
≤ 56 years old, OR (95% CI)	1.00	1.32 (0.85, 2.05)	1.32 (0.84, 2.07)	1.31 (0.83, 2.06)	1.46 (0.91, 2.34)	0.17
Cases/Controls	49/79	54/98	63/117	62/105	55/120
> 56 years old, OR (95% CI)	1.00	0.89 (0.55, 1.46)	0.86 (0.54, 1.37)	0.94 (0.58, 1.52)	0.69 (0.41, 1.17)	0.21
Cases/Controls	111/222	119/221	120/224	126/222	116/223
Total	1.00	1.08 (0.78, 1.50)	1.07 (0.78, 1.48)	1.13 (0.82, 1.57)	1.04 (0.73, 1.47)	0.84

¹Adjusted by month of blood draw (see Methods Section)

²Quintiles based on distribution of ages, sex and date of blood draw- matched controls

³Tests for linear trend treated median exposure in each quintile as continuous