Skip to main content
. Author manuscript; available in PMC: 2016 Apr 11.
Published in final edited form as: Mol Psychiatry. 2014 Jun 10;19(9):1037–1043. doi: 10.1038/mp.2014.58

Figure 1.

Figure 1

Behavioral effects of intravenous methylphenidate (MP). (a) Self-reports of ‘high’ in the controls and in cocaine abuser both when MP was given concomitant to cocaine cue-video or when it was given with the neutral-video. *Significantly different from controls (P < 0.05). (b) Scores on cocaine craving questionnaire (CCQ) in the cocaine abusers at baseline (prior to any stimulation), 20 min after exposure to the cocaine cue- or the neutral-video, 30 min after MP (end of 50 min of video stimulation) and 60 min after MP. *Significantly different from baseline measures at P < 0.05 and at ***P < 0.001. (c) Correlations between MP-induced changes in non-displaceable binding potential (BPND) in ventral striatum (VS) and the changes in craving scores (cocaine craving questionnaire or CCQ) both when it was given with the cocaine cues-video (r = − 0.51, P =0.02) and when given with the neutral-video (r = − 0.50, P=0.02).