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. Author manuscript; available in PMC: 2016 Apr 11.
Published in final edited form as: AIMS Biophys. 2015 Dec 1;2(4):794–809. doi: 10.3934/biophy.2015.4.794

Figure 3.

Figure 3

The cancer-specific molecular interactions of the lncRNA-MYC network at the 8q24 genomic region. CCAT1 both transcriptionally (through chromatin interactions) and post-transcriptionally (through titration of let-7) regulates MYC expression. CCAT2 stimulates TCFL2-mediated transcription of the MYC locus. PCAT1 prevents miR34-a mediated translational repression. PVT1 binds to MYC preventing threonine-58 phosphorylation by glycogen synthase kinase 3 (GSK3) and subsequent MYC degradation. Collectively, all of the flanking lncRNAs promote the accumulation of MYC; therefore, when these lncRNA are inappropriately upregulated, MYC-dependent malignancies can develop.