Table 1.

Summary of the participants of the lncRNA-MYC network.

LncRNA	Aliases	Functional category	Chromosome	Regulated by MYC	Regulates MYC	Classification	Function	References
PVT1	LINC0007, onco-lncRNA-100	Decoy	8	Upregulated	Yes	Oncogene	Binds MYC preventing phosphorylation and degradation	[45,47,48]
CCAT Family
CCAT1	CARLo5, onco-lncRNA-40	Guide, scaffold, decoy	8	Upregulated	Yes	Oncogene	Facilitates transcription of MYC, titrates let-7 away preventing MYC degradation	[52,54,58–61,63–65]
CCAT2	NCCP1, LINC00873	Guide	8	Unknown	Yes	Oncogene	Facilitates transcription of MYC via the stimulation of TCF7L2	[62]
MYCLo1	AK021907	Unknown	20	Upregulated	Unknown	Oncogene	–	[63]
MYCLo2	CCAT6, AC074389.9	Unknown	7	Upregulated	Unknown	Oncogene	–	[63]
MYCLo3	KTN1-AS1, C14orf33	Unknown	14	Upregulated	Unknown	Oncogene	–	[63]
MYCLo4	JX046912	Unknown	9	Downregulated	Unknown	Tumor suppressor	–	[66]
MYCLo5	JX046913, JX046914	Unknown	3	Downregulated	Unknown	Tumor suppressor	–	[66]
MYCLo6	JX046915	Unknown	3	Downregulated	Unknown	Tumor suppressor	–	[66]
PCAT Family
PCAT1	PCA1	Unknown	8	Unknown	Yes*	Oncogene	Interferes with miR34-a preventing MYC translational repression	[67]
PCAT9	PCGEM1, LINC00071	Unknown	2	Unknown	Yes	Oncogene	Increases MYC transactivation activity	[75]
GAS5	SNHG2	Unknown	1	Unknown	Yes	Tumor suppressor	Prevents translation of MYC mRNA	[82]
GHET1	–	Guide, scaffold	7	Unknown	Yes	Oncogene	Promotes stability of MYC mRNA via the recruitment of IGF2BP1	[84]
H19	ASM, BWS, WT2, ASM1, D11S813E, LINC00008	Decoy	11	Upregulated	Yes	Tumor suppressor/oncogene	Titrates let-7 away preventing MYC mRNA degradation	[93,94,97]
TUSC8	XLOC_010588, LINC01071	Unknown	13	Unknown	Yes*	Tumor suppressor	–	[98]

^*Unclear whether effect is direct or indirect