Table 1. Oncology Panel in Vitro Data.
| entry | cell line | IC50 μM reported in the lit.a | IC50 μM for 1b (72 h)c,d | IC50 μM for 15 (72 h)c,e |
|---|---|---|---|---|
| 1 | MDA-MB-231 | 2.6 ± 0.05f | 19 ± 1.6 | >25 |
| 2 | HepG2 | 4.3 ± 0.03f | >25 | >25 |
| 3 | LNCaP | 6.1 ± 0.07f | 22 ± 5.4 | >25 |
| 4 | Hep 3B | 0.13 ± 0.02f | 8.9 ± 2.1 | >25 |
| 5 | PANC-1 (48 h)c | 19g,h | >25 | >25 |
| 6 | AsPC-1 (48 h)c | 20g,h | >25 | >25 |
| 7 | A549 (12 h)c | 25i | 6.7 ± 2.5 | 10.8 ± 5.8 |
| 8 | H441 | 25i | >25e | >25 |
a
Source of cell line reported in the literature. MDA-MB-231: CCRC-60425. HepG2: BCRC-60025. LNCaP: CCRC-60088. Hep 3B: BCRC-60434. PANC-1: ATCC. AsPC-1: ATCC. A549: KMUH. H441: KMUH.
b
Source of cell lines reported in this paper: ATCC.
c
Incubation time.
d
Triplicate data.
e
Duplicate data.
f
Reference (1).
g
Reference (2f).
h
SRB assay.
i
Reference (2c).