Table III.
Gene/SNP | Control group (n=35) a | Case group (n=35) a | P-value |
---|---|---|---|
Genotype and allele-wise comparisons | |||
VDR/FokI | |||
FF: Ff: ff | 24 (68.6): 10 (28.6): 1 (2.8) | 16 (45.7): 17 (48.6): 2 (5.7) | 0.153 |
F: f | 58 (82.9): 12 (17.1) | 49 (70.0): 30 (21.0) | 0.073 |
VDR/BsmI b | |||
BB: Bb: bb | 5 (14.3): 23 (65.7): 7 (20.0) | 10 (28.6): 12 (34.3): 13 (37.1) | 0.031 |
B: b | 33 (47.1): 37 (52.9) | 32 (45.7): 38 (54.3) | 0.865 |
VDR/ApaI c | |||
AA: Aa: aa | 8 (22.9): 21 (60.0): 6 (17.1) | 15 (42.9): 11 (31.4) : 9 (25.7) | 0.054 |
A: a | 37 (52.9): 33 (47.1) | 41 (58.6): 29 (41.4) | 0.496 |
VDR/Tru9I | |||
RR: Rr: rr | 27 (77.1): 8 (22.9): 0 (0.0) | 28 (80.0): 6 (17.1): 1(2.9) | 0.521 |
R: r | 62 (88.6): 8 (11.4) | 62 (88.6): 8 (11.4) | 1.000 |
VDR/ TaqI | |||
TT: Tt: tt | 15 (42.9): 16 (45.7): 4 (11.1) | 15 (42.9): 14 (40.0): 6 (17.1) | 0.766 |
T: t | 46 (65.7): 24 (34.3) | 44 (62.9): 26 (37.1) | 0.724 |
PTH/DraII | |||
DD: Dd: dd | 0 (0.0): 16 (45.7) : 19 (54.3) | 1 (2.9): 9 (25.7): 25 (71.4) | 0.151 |
D: d | 19 (27.1): 51 (72.9) | 11 (15.7): 59(84.3) | 0.099 |
INSR/NsiI | |||
NN: Nn: nn | 21 (60.0) : 12 (34.3) : 2 (5.7) | 18 (51.4): 12 (34.3): 5 (14.3) | 0.468 |
N: n | 54 (77.1): 16 (22.9) | 48 (68.6): 22 (31.4) | 0.254 |
INSR/PmlI | |||
PP: Pp: pp | 1 (2.9) : 16 (45.7) : 18 (51.4) | 0 (0.0): 14 (40.0): 21 (60.0) | 0.506 |
P: p | 18 (25.7): 52 (74.3) | 14 (20.0): 56 (80.0) | 0.424 |
VDR: Vitamin D receptor; PTH: Parathyroid hormone; INSR: Insulin receptor.
Data are presented as number (%),
chi-square test for genotype-wise comparisons: BB/Bb + bb (p= 0.152; OR= 2.400, 95% CI= 0.725-7.949), Bb/BB + bb (p= 0.010; OR= 0.272, 95%CI= 0.101-730), and bb/ BB + Bb (p= 0.117; OR= 2.364, 95%CI= 0.807-6.927) test models, respectively.
chi-square test for genotype-wise comparisons: AA/Aa+aa (p=0.079; OR=2.531, 95% CI=0.899-7.124), Aa/AA+aa (p=0.018; OR=0.306, 95%CI=0.114-0.817), and aa/AA+Aa (p= 0.079; OR= 1.673, 95%CI= 0.524-5.341) test models, respectively.