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. 2015 Dec;13(12):793–800.

Table III.

Association between genotypes and alleles of VDR, PTH, and INSR gene polymorphisms and risk of PCOS

Gene/SNP Control group (n=35) a Case group (n=35) a P-value
Genotype and allele-wise comparisons
VDR/FokI
FF: Ff: ff 24 (68.6): 10 (28.6): 1 (2.8) 16 (45.7): 17 (48.6): 2 (5.7) 0.153
F: f 58 (82.9): 12 (17.1) 49 (70.0): 30 (21.0) 0.073
VDR/BsmI b
BB: Bb: bb 5 (14.3): 23 (65.7): 7 (20.0) 10 (28.6): 12 (34.3): 13 (37.1) 0.031
B: b 33 (47.1): 37 (52.9) 32 (45.7): 38 (54.3) 0.865
VDR/ApaI c
AA: Aa: aa 8 (22.9): 21 (60.0): 6 (17.1) 15 (42.9): 11 (31.4) : 9 (25.7) 0.054
A: a 37 (52.9): 33 (47.1) 41 (58.6): 29 (41.4) 0.496
VDR/Tru9I
RR: Rr: rr 27 (77.1): 8 (22.9): 0 (0.0) 28 (80.0): 6 (17.1): 1(2.9) 0.521
R: r 62 (88.6): 8 (11.4) 62 (88.6): 8 (11.4) 1.000
VDR/ TaqI
TT: Tt: tt 15 (42.9): 16 (45.7): 4 (11.1) 15 (42.9): 14 (40.0): 6 (17.1) 0.766
T: t 46 (65.7): 24 (34.3) 44 (62.9): 26 (37.1) 0.724
PTH/DraII
DD: Dd: dd 0 (0.0): 16 (45.7) : 19 (54.3) 1 (2.9): 9 (25.7): 25 (71.4) 0.151
D: d 19 (27.1): 51 (72.9) 11 (15.7): 59(84.3) 0.099
INSR/NsiI
NN: Nn: nn 21 (60.0) : 12 (34.3) : 2 (5.7) 18 (51.4): 12 (34.3): 5 (14.3) 0.468
N: n 54 (77.1): 16 (22.9) 48 (68.6): 22 (31.4) 0.254
INSR/PmlI
PP: Pp: pp 1 (2.9) : 16 (45.7) : 18 (51.4) 0 (0.0): 14 (40.0): 21 (60.0) 0.506
P: p 18 (25.7): 52 (74.3) 14 (20.0): 56 (80.0) 0.424

VDR: Vitamin D receptor; PTH: Parathyroid hormone; INSR: Insulin receptor.

a

Data are presented as number (%),

b

chi-square test for genotype-wise comparisons: BB/Bb + bb (p= 0.152; OR= 2.400, 95% CI= 0.725-7.949), Bb/BB + bb (p= 0.010; OR= 0.272, 95%CI= 0.101-730), and bb/ BB + Bb (p= 0.117; OR= 2.364, 95%CI= 0.807-6.927) test models, respectively.

c

chi-square test for genotype-wise comparisons: AA/Aa+aa (p=0.079; OR=2.531, 95% CI=0.899-7.124), Aa/AA+aa (p=0.018; OR=0.306, 95%CI=0.114-0.817), and aa/AA+Aa (p= 0.079; OR= 1.673, 95%CI= 0.524-5.341) test models, respectively.