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. 2016 Apr 5;11:1413–1425. doi: 10.2147/IJN.S95850

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© 2016 Han et al. This work is published and licensed by Dove Medical Press Limited

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Antitumor effect of various GEM formulations in a BCSC xenograft model.

Notes: Tumor growth (A) and body weight changes (B) were monitored for 21 days. Mice were treated twice a week (indicated by arrows in the figure) as follows: DPBS (control), free GEM (25 mg/kg), L-GEM (25 mg/kg), and HA-L-GEM (25 mg/kg). Data shown represent the mean ± SE (^*P<0.05, ^**P<0.01).

Abbreviations: BCSC, breast cancer stem cell; GEM, gemcitabine; DPBS, Dulbecco’s phosphate-buffered saline; HA-L, hyaluronan-liposomal; SE, standard error; L-GEM, liposomal GEM; HA-L-GEM, HA-conjugated liposomal GEM; free GEM, GEM in solution.