Table 2.
Structure and activity of Top 20 hits against B. burgdorferi
| Serial number | Drugs | Structure | % inhibition | MIC (µM) |
MBC (µM) |
|---|---|---|---|---|---|
| Control (no drug) | – | 0 | |||
| Doxycycline | – | 94.14 | |||
| 1 | Tetraethylthiuram disulfde |
|
99.80 | 0.625 | 1.25 |
| 2 | Doxorubicin hydrochloride |
|
99.70 | 0.625 | 1.25 |
| 3 | Josamycin |
|
99.63 | 15.0 | 20.0 |
| 4 | Cefotaxime acid |
|
99.47 | 2.0 | 3.0 |
| 5 | Cefazolin sodium |
|
99.20 | 1.25 | 12 |
| 6 | Epirubicin hydrochloride |
|
99.10 | 0.3 | 0.625 |
| 7 | Erythromycin |
|
99.04 | 15.0 | 20.0 |
| 8 | A-23187 calcimycin |
|
98.82 | 10.0 | 20.0 |
| 9 | Gramicidin | Formyl-L-X-Gly-L-Ala-D-Leu-L-Ala-D-Val-L-Val-D-Val-L-Trp-D-Leu-L-Y-D-Leu-L-Trp-D-Leu-L-Trp-ethanolamine X = Val/Ile, Y = Trp/Phe/Tyr | 98.67 | 1.25 | 2.5 |
| 10 | Cefdinir |
|
98.50 | 3.0 | 25.0 |
| 11 | Gambogic acid |
|
98.41 | 10.0 | 20.0 |
| 12 | Cephalothin sodium |
|
98.38 | 2.5 | >80 |
| 13 | Ceftazidime |
|
98.23 | 30.0 | 40.0 |
| 14 | Ticarcillin disodium |
|
98.16 | 10.0 | 45.0 |
| 15 | Valinomycin |
|
97.97 | 15.0 | 40.0 |
| 16 | Moxifoxacin hydrochloride |
|
97.68 | 7.5 | 12.5 |
| 17 | Linezolid |
|
97.58 | 0.625 | 25.0 |
| 18 | Idarubicin hydrochloride |
|
97.4 | 5.0 | 10.0 |
| 19 | Tosufoxacin tosylate |
|
97.27 | 45.0 | >80 |
| 20 | Azlocillin sodium |
|
95.25 | 1.25 | 2.5 |
Abbreviations: MBC, minimum bactericidal concentration; MIC, minimum inhibitory concentration.