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. Author manuscript; available in PMC: 2016 Apr 11.
Published in final edited form as: Sci Transl Med. 2015 Jul 29;7(298):298ra117. doi: 10.1126/scitranslmed.aaa7619

Figure 5. Low concentrations of resveratrol activate AMPK and increase markers of oxidative stress in human colorectal tissues.

Figure 5

Exposure to resveratrol (2h) increases pAMPK levels and up-regulates autophagy in primary colorectal cancer explants, as assessed by Western blotting (a) and/or immunohistochemical staining (b) in samples from three different patients. Expression of NQO1 (c–d) and levels of protein carbonylation (e) in colorectal mucosa tissue of patients participating in the [14C]-resveratrol trial who received a dose of either 5 mg or 1 g daily for one week prior to surgery, or untreated control patients. Samples were analysed blind, and significant differences between control and treated groups are indicated. (c) A typical Western blot for NQO1. (d) Data represent the mean ± SEM of 6–8 patients per group. (e) Data show the mean ± SEM of 4–6 patients per group.