Table 5.
Significant interactions between ApoE4 and midlife cardiovascular risk factor exposure on NP outcome measures
ApoE4− | ApoE4+ | ||||
TMA | |||||
Beta (SE) | p-value | Beta (SE) | p-value | p-value for Interaction | |
HTN | −0.002 ± 0.15 | 0.990 | −0.67 ± 0.36 | 0.065 | 0.052 |
COWAT | |||||
Beta (SE) | p-value | Beta (SE) | p-value | p-value for Interaction | |
SBP | −0.004 ± 0.004 | 0.288 | −0.023 ± 0.010 | 0.025 | 0.074 |
ApoE4−, participants without the apolipoprotein ε4 allele; ApoE4+, participants with the apolipoprotein ε4 allele; HTN, hypertension; SBP, systolic blood pressure; Beta, estimate; SE, standard error; TMA, Trail-making Test A completion time; COWAT, Controlled Word Association Test; Bold values are statistically significant.