Skip to main content
. Author manuscript; available in PMC: 2016 Apr 11.
Published in final edited form as: J Metabolomics. 2015 Apr 4;1:1. doi: 10.7243/2059-0008-1-1

Figure 1. Oxylipins produced from fatty acid precursor via the cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome P450 (CYP) enzymatic pathways.

Figure 1

The fatty acids linoleic acid (LA, 18:2n6), arachidonic acid (ARA, 20:4n6), dihomo-γ-linolenic acid (DGLA, 20:3n6), α-linolenic acid (ALA, 18:3n3), eicosapentaenoic acid (EPA, 20:5n3), and docosahexaenoic acid (DHA, 22:6n3) are precursors for prostaglandins (PGE1, PGD1, PGF2a. PGE2, PGD2, 6-keto-PGF1a), thromboxane (TXB2), hydroxyeicosatetraenoic acids (HETEs), hydroxyeicosaptenaenoic acids (HEPEs), hydroxydocosahexaenoic acid (17-HDoHE), leukotriene (LTB4), hydroxyoctadienoic acids (HODEs), trihydroxyoctamonoenoic acids (TriHOMEs), oxo-octadecadienoic acids (oxo-ODEs), hydroxyeicosatrienoic acid (15-HETrE), hydroxyoctadecatrienoic acids (HOTEs), oxo-eicosatetraenoic acid (15-oxo-ETE), epoxyeicosatrienoic acids (EETs), epoxyoctadecadienoic acids (EpODEs), epoxyoctamonoenoic acids (EpOMEs), epoxyeicosatetreaenoic acids (EpETEs), epoxydocosapentaenoic acids (EpDPEs), as well as the downstream soluble epoxide hydrolase (sEH) metabolites dihydroxyoctamonoenoic acids (DiHOMEs), dihydroxyeicosatrienoic acids (DHETs), dihydroxyoctadecadienoic acids (DiHODEs), dihydroxyeicosatetraenoic acids (DiHETEs), and dihydroxydocosapentaenoic acids (DiHDPEs). Each fatty acid precursor and its oxylipin products have the same color [16].