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. Author manuscript; available in PMC: 2016 Apr 11.
Published in final edited form as: Curr Opin Cell Biol. 2007 Oct 17;19(5):578–583. doi: 10.1016/j.ceb.2007.09.005

Figure 3.

Figure 3

Proposed model of fibronectin fibrillogenesis [50••]. (A) FN exists in a globular, soluble state in plasma. The interdomain interactions defining this state are disrupted by cell-generated tension (B). (C) The N-termini of two extended FN molecules form a tight complex through the FN 30 kDa-1-2FNIIIopen interaction, thereby creating FN protofibrils.