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. Author manuscript; available in PMC: 2016 Jul 20.
Published in final edited form as: Expert Opin Drug Metab Toxicol. 2015 Jul 20;11(11):1769–1779. doi: 10.1517/17425255.2015.1071353

Table II.

Other kinases and phosphatases involved in JNK signaling

Kinase/phosphatase Effect on JNK activation [ref.] Upstream / Downstream of JNK
GSK3β Activator (early time points?) [56] Upstream
MLK3 Activator (early time points?) [57] Upstream
ASK1 Activator (late time points) [54] Upstream
RIP1 Activator [73,77] Upstream
RIP3 Activator? [76] Upstream?
Mkp-1 Inhibitor [64] Downstream
PTP1B Inhibitor?* [69] Downstream?*
*

The expected effect is decreased JNK activation, but the published results appear to be heavily influenced by other effects.