Table 3. Brain regions with significant metabolic differences between PD groups (p<0.01 uncorrected).
| Regions | BA | MNI coordinatea | Zmax | Cluster size (mm3) | |||
|---|---|---|---|---|---|---|---|
| x | y | z | |||||
| PD-MCI VS.PD-NCb | |||||||
| Increased metabolism | Lt postcentral gyrus | 5 | -18 | -46 | 70 | 4.07 | 32600 |
| Lt paracentral lobule | 4 | -10 | -44 | 74 | 3.91 | ||
| Rt precentral gyrus | 4 | 18 | -38 | 72 | 3.63 | ||
| Decreased metabolism | Lt superior temporal gyrus | 22 | -62 | -4 | -2 | 3.81 | 1024 |
| Lt posterior cingulate | 30 | -24 | -70 | 10 | 3.36 | 976 | |
| Rt precentral gyrus | 6 | 44 | 22 | 38 | 3.15 | 1376 | |
| Rt superior frontal gyrus | 10 | 42 | 62 | 0 | 3.14 | 1064 | |
| Lt parahippocampal gyrus | 19 | -20 | -46 | -10 | 3.07 | 1304 | |
| PDD VS. PD-MCI | |||||||
| Increased metabolism | Lt cingulate gyrus | 24 | -2 | 2 | 42 | 3.09 | 2184 |
| Decreased metabolism | Lt precentral gyrus | 6 | -66 | -16 | 34 | 4.19 | 1400 |
| Rt superior frontal gyrus | 8 | 20 | 26 | 50 | 3.35 | 2184 | |
| Lt supramarginal gyrus | 40 | -60 | -46 | 28 | 3.32 | 3568 | |
| Lt inferior parietal lobule | 40 | -58 | -50 | 40 | 2.93 | ||
| Lt superior parietal lobule | 7 | -28 | -56 | 40 | 2.62 | ||
| Rt angular gyrus | 39 | 34 | -64 | 38 | 3.24 | 1376 | |
| Lt precuneus | 31 | -12 | -68 | -20 | 2.93 | 1400 | |
| Lt cuneus | 17 | -20 | -82 | 4 | 2.42 | 648 | |
| PDD VS. PD-NC | |||||||
| Increased metabolism | Rt paracentral lobule | 6 | 12 | -36 | 66 | 4.12 | 30928 |
| Decreased metabolism | Lt middle temporal gyrus | -60 | -48 | -4 | 3.61 | 2736 | |
| Rt inferior frontal gyrus | 9 | 44 | 10 | 32 | 3.39 | 1440 | |
| Rt superior frontal gyrus | 8 | 44 | 16 | 56 | 3.24 | 1592 | |
| Rt middle frontal gyrus | 9 | 48 | 30 | 42 | 2.82 | ||
| Rt inferior parietal lobule | 39 | 36 | -66 | 40 | 3.23 | 5432 | |
| Rt supramarginal gyrus | 40 | 62 | -56 | 32 | 3.16 | ||
| Lt cuneus | 18 | -24 | -72 | 14 | 3.02 | 1624 | |
| Lt posterior cingulate | 30 | -10 | -62 | 14 | 2.69 | ||
| Rt precuneus | 7 | 14 | -70 | 30 | 2.97 | 1176 | |
| Rt precuneus | 31 | 18 | -64 | 20 | 2.91 | ||
| Lt precuneus | 19 | -40 | -78 | 34 | 2.96 | 2120 | |
| Rt middle temporal gyrus | 21 | 60 | -50 | 4 | 2.96 | 1272 | |
BA, Brodmann area; MNI, Montreal Neurological Institute; PD-NC, Parkinson’s disease with no cognitive impairment; PD-MCI, Parkinson’s disease with mild cognitive impairment; PDD, Parkinson’s disease with dementia; Lt, Left; Rt, Right.
a MNI standard space.
b Survived at uncorrected P < 0.01, extent threshold = 80 voxels (640 mm3).