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. 2016 Apr 11;11(4):e0153136. doi: 10.1371/journal.pone.0153136

Fig 3. Mass spectrometric analysis of urine GAGs in age-matched normal, untreated and PPS-treated MPS I dogs.

Fig 3

Mass spectrometric quantification of GAG-derived disaccharides was performed as described in the Material and Methods. Urine GAGs were measured at the end of the treatment; 17 months with oral daily PPS and 12 months with biweekly subQ PPS. Black columns, untreated MPS I dogs; white columns, oral PPS-treated MPS I dogs; grey columns, subQ PPS-treated MPS I dogs. The vertical lines in each column indicate the ranges. Dashed lines represent normal levels. (A) The dermatan sulfate disaccharide (Di-6S) was significantly reduced with both modes of PPS administration, with subQ treatment being more significant. * p = 0.0232 comparing untreated to oral and p = 0.0141 comparing untreated to subQ. (B) Heparan sulfate disaccharides (DiHS-OS, DiHS-6S, and DiHS-NS) also were reduced with PPS treatment when compared to untreated animals, although the reductions were not significant.