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. 2016 Apr 11;11(4):e0153136. doi: 10.1371/journal.pone.0153136

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© 2016 Simonaro et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 5 — (A) Normal (B) Storage (arrowhead) and elastin fragmentation (arrow) is evident in the aortas of untreated 12-month-old MPS I dogs (B) Reduced storage (arrowheads) and fragmentation was observed in MPS I animals treated with oral PPS (daily) for 17 months. (C) Little or no storage or fragmentation was evident in the subQ treated animals (biweekly for 12 months). (20X magnification).