Table 1. Clinicopathological associations of BRAF V600E and TERT promotermutations.
| Parameter | BRAFV600E mutation(N = 455) | p Value | TERT promoter mutation(s) (N = 434) | p Value | ||
|---|---|---|---|---|---|---|
| Positive | Negative | Positive | Negative | |||
| Number of patients | 343(75.4%) | 112(24.6%) | 19(4.4%) | 415(95.6%) | ||
| Gender | 0.389 | 0.791 | ||||
| F | 246(71.7%) | 85(75.9%) | 15(78.9%) | 305(73.5%) | ||
| M | 97(28.3%) | 27(24.1%) | 4(21.1%) | 110(26.5%) | ||
| Age(years) | <0.001 | <0.001 | ||||
| mean±SD | 42.5±11.1 | 36.8±12.9 | 52.79±4.74 | 40.40±1.11 | ||
| 95% Confidence Interval | 41.32–43.67 | 34.33–39.19 | 47.70–57.87 | 39.29–41.51 | ||
| Size(mm) | 0.272 | 0.024 | ||||
| Median quartiles | 10.00(6.00–15.00) | 10.50(6.25–15.75) | 14.00(8.00–22.00) | 10.00(6.00–15.00) | ||
| Multifocality | 0.717 | 0.302 | ||||
| single | 242(75.9%) | 77(68.8%) | 11(57.9%) | 294(70.8%) | ||
| multifocal | 101(74.3%) | 35(31.3%) | 8(42.1%) | 121(29.2%) | ||
| Variants types | 0.001 | 0.022 | ||||
| Conventional | 245 (71.4%) | 64(57.1%) | 13(68.4%) | 282(68.0%) | ||
| follicular | 66 (19.2%) | 36(32.1%) | 1(5.3%) | 97(23.4%) | ||
| solid | 27(7.9%) | 8(7.1%) | 4(21.1%) | 29(7.0%) | ||
| other | 5(1.5%) | 4(3.6%) | 1(5.3%) | 7(1.7%) | ||
| LN metastasis | 0.24 | 0.054 | ||||
| yes | 261(76.1%) | 79(79.5%) | 18(94.7%) | 309(74.5%) | ||
| no | 82(23.9%) | 33(20.5%) | 1(5.3%) | 106(25.5%) | ||
| TNM stage | 0.09 | <0.001 | ||||
| I-II | 248(72.3%) | 90(80.4%) | 6(31.6%) | 316(76.1%) | ||
| III-IV | 95(27.7%) | 22(19.6%) | 13(68.4%) | 99(23.9%) | ||