Table 2. Risk factors for developing TB adjusted by age at entry, sex, the use of corticosteroids, comorbidities and Charlson comorbidity index (CCI) in rheumatoid arthritis cohort.
| Risk factors | Adjusted HR | 95% CI | p-value |
|---|---|---|---|
| Age at entry, years | |||
| 18–44 | 1.00 (reference) | - | - |
| 45–64 | 2.16 | 1.81–2.14 | <0.0001 |
| ≧65 | 4.37 | 1.91–2.44 | <0.0001 |
| Gender | |||
| Female | 1.00 (reference) | - | - |
| Male | 1.87 | 1.70–2.05 | <0.0001 |
| Use of corticosteroids | |||
| No | 1.00 (reference) | - | - |
| Yes | 1.88 | 1.69–2.10 | <0.0001 |
| Use of corticosteroids | |||
| Daily dose <5mg | 1.00 (reference) | - | - |
| Daily dose≧5mg | 2.70 | 2.43–3.01 | <0.0001 |
| CCI | |||
| 0 | 1.00 (reference) | - | - |
| 1 | 1.23 | 1.12–1.34 | <0.0001 |
| 2 | 1.22 | 1.09–1.36 | 0.0007 |
| ≧3 | 1.21 | 1.06–1.39 | 0.006 |
| Comarbidity | |||
| Diabetes mellitus | 1.26 | 1.14–1.40 | <0.0001 |
| Liver cirrhosis | 0.93 | 0.83–1.05 | 0.248 |
| COPD | 1.51 | 1.38–1.66 | <0.0001 |
| CKD | 1.44 | 1.08–1.91 | 0.013 |
HR: hazard ratio; 95%CI: 95% confidence interval; COPD: chronic obstructive pulmonary disease; CKD: chronic kidney disease.