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. 2016 Apr 11;11(4):e0152860. doi: 10.1371/journal.pone.0152860

Fig 1. An iterative process of integrating and discovering miRNA regulatory relationships.

Fig 1

Our proposed framework is one iteration of the above knowledge and data integrated discovery process. In the long run, wet-lab and dry-lab discoveries become an integrated feedback process for uncovering new biological insights. Bayesian network based causal reasoning provides an excellent platform for a seamless integration.