Table 1. Genetic characteristics of mAbs isolated from animal DBM5 by CD4bs competition B cell sort.
Clonally related mAbs share mAb ID numbers (i.e. ITS07) with additional numbering to denote individual clonal members (i.e. ITS07.01 and ITS07.02)
| mAb ID | Rhesus heavy chain V gene | % Divergence (nt) from germline | CDRH3 | Rhesus light chain V gene | % Divergence (nt) from germline | CDRL3 |
|---|---|---|---|---|---|---|
| ITS01 | IGHV4B*02 | 7% | ARGGNIWTGYHSTYFYY | IGLV1-14*01 | 6% | QSFDSSVSVQV |
| ITS02 | IGHV4C*01 | 2% | ARDRSSYYTRGLDS | IGLV3-1*01 | 1% | QVWDSSSDHYI |
| ITS07.01 | IGHV3M*01 | 10% | VRDGALDCTGSGCWVFDY | IGLV5-14*01 | 5% | AIGHSRGYT |
| ITS07.02 | IGHV3M*01 | 10% | VRDGALDCTGSSCWVFDY | IGLV5-14*01 | 4% | AIGHSRGYT |
| ITS08 | IGHV4G*02 | 10% | ARTWGIFGLVKNMRFDV | IGKV2S17*01 | 2% | MQGLEFPLT |
| ITS16.01 | IGHV4L*02 | 5% | ARHSAGITAAWIGGNRRKTDY | IGKV1-12*01 | 3% | QQYNSDPHS |
| ITS16.02 | IGHV4L*02 | 6% | ARHSAGLTAAWIGGRRRKTDY | IGKV1-12*01 | 3% | QQYTSDPHS |
| ITS16.03 | IGHV4L*02 | 6% | ARHSAGLTAAWIGGRRRKTDY | IGKV1-12*01 | 4% | QQYNSDPHS |
| ITS19 | IGHV4L*03 | 6% | ARHSAGLTAAWIGGSRRKTDY | IGKV1-14*01 | 2% | QQRNGYPWT |
| ITS20 | IGHV4L*02 | 7% | ARHSTGLTAAWIGGRRRKIDY | IGKV3-5*01 | 6% | QETSDLFT |
| ITS23 | IGHV4F*02 | 11% | ARDETKFGLVVS | IGLV1-7*01 | 5% | QSYDTNLRIL |
| ITS27 | IGHV4G*01 | 11% | ARGSNIWTSYYDNWFDV | IGLV1S1*01 | 8% | STWDSSLSTGL |
| DBM5.2E10 | IGHV4K*01 | 6% | ASDLLDFWTGYYTGWFDV | IGKV1-14*01 | 3% | QQRNGYPWT |
| DBM5.2E11 | IGHV4K*01 | 6% | ASDLLDFWTGYYTGWFDV | IGKV1-12*01 | 4% | QQYNSDPHS |
| DBM5.2B3 | IGHV4K*01 | 6% | ASDLLDFWTGYYTGWFDV | IGKV2S17*01 | 2% | MQGLEFPLT |
| DBM5.1A11 | IGHV7-B*01 | 10% | ARRGFYWSDRGLDS | IGKV3S7*01 | 9% | QQTGDWPLS |