Table 2. Genetic characteristics of mAbs isolated from CVNbs competition B cell sort.
| mAb ID | Animal | Rhesus heavy chain V gene | % Divergence (nt) from germline | CDRH3 | Rhesus light chain V gene | % Divergence (nt) from germline | CDRL3 |
|---|---|---|---|---|---|---|---|
| ITS50 | 05D247 | IGHV4L*03 | 1% | ARANYEDDYGYYYKWGGVFDY | IGKV1-21*01 | 1% | QQYDDLPYS |
| ITS51 | 05D247 | IGHV1E*01 | 4% | AASRSGNWYFDL | IGLV4S4*01 | 3% | QTWTNGIVL |
| ITS52 | 05D247 | IGHV4A*02 | 5% | ACPLSGGLNYVLDV | IGKV1-21*01 | 8% | LQYTTSPWT |
| ITS53 | 05D247 | IGHV3W*02 | 5% | ATMDL | IGKV2S18*01 | 9% | MQTLQTPFS |
| ITS54 | 05D247 | IGHV4I*01 | 4% | ARLTVRRLDV | IGKV1S24*01 | 10% | QHGYGTPLT |
| ITS55 | 05D247 | IGHV4L*03 | 6% | AREIGTTIIFRE | IGKV1S26*01 | 4% | QQGNSKPFT |
| ITS56 | A4V014 | IGHV1I*01 | 0% | ARAQGVYYEDDYGLYFDY | IGLV5-7*01 | 1% | TWHGNSKTVL |
| ITS57 | A4V014 | IGHV3K*01 | 7% | AMGSGGHSSRDVFDF | IGKV1-13*01 | 2% | LQGYDPPYS |
| ITS58 | A4V014 | IGHV7B*01 | 1% | ARWDWILQSLDWRVNSLDV | IGKV2S5*01 | 8% | MQGTHFPLT |
| ITS59 | A4V014 | IGHV3W*01 | 4% | TRDLPYTSWCRGDY | IGLV1-15*01 | 7% | AAWDDSLSGVL |
| ITS60 | A4V014 | IGHV4F*01 | 1% | ARAFWGYEDDYGYSDNGVYFDS | IGLV3-1*01 | 4% | QVWDFSSDHPI |
| ITS61.01 | ZB08 | IGHV3K*01 | 7% | VKGMRGDHEVESFEQIIAADPQGDV | IGKV2S17*01 | 5% | MQGVEFPWT |
| ITS61.02 | ZB08 | IGHV3K*01 | 8% | VKGMRGDIEVESFAQIIAADPAGDV | IGKV2S17*01 | 4% | MQGVEFPWT |
| ITS62 | ZB08 | IGHV4F*01 | 11% | ASILTGLEFDF | IGLV3-1*01 | 10% | QVWDISGDHMF |
| ITS63 | ZB08 | IGHV4F*01 | 8% | ASGYSGYSPFDY | IGKV1S9*01 | 12% | QHNYGTPWT |
| ITS64 | ZB08 | IGHV4F*01 | 7% | ARDSGIAAGEFDY | IGKV1-22*01 | 8% | QQYNSSPFT |
| ITS65 | ZB08 | IGHV3D*01 | 2% | AGDYDYGSNFLVDY | IGKV2S11*01 | 2% | VQVIAFPFT |
| ITS66.01 | ZB08 | IGHV3J*01 | 3% | ATGGWLLPFGY | IGLV1S1*01 | 8% | GAWDSSLSAGL |
| ITS66.02 | ZB08 | IGHV3J*01 | 5% | STGGWLLPFGY | IGLV1-13*01 | 6% | GAWDSSLSAGL |
| ITS67 | ZB08 | IGHV4F*01 | 7% | ARDGEATFDS | IGKV3-8*01 | 1% | QQENSTPT |
| ITS68 | ZB08 | IGHV7B*01 | 2% | ARQSRENTGFDY | IGKV3S6*01 | 1% | QQESNWSLT |
| ITS69 | ZB08 | IGHV1F*02 | 1% | ARTGIQWAQLDLGENYY | IGLV3-6*01 | 5% | QVWDSSSKYVL |
| ITS70 | ZB42 | IGHV4L*03 | 6% | ARDLVDSEYEVVWFDV | IGLV1-13*01 | 3% | GAWDTSLSARV |
| ITS71 | ZB42 | IGHV3L*01 | 5% | TRGSGWSEGNEEYFEF | IGLV6-5*01 | 6% | QSFDSNTYWL |
| ITS72 | ZB42 | IGHV1E*02 | 5% | ARGPRYEDDYGYYDWYFDL | IGLV3-1*01 | 7% | QVWDLSSDHVL |
| ITS73 | ZB42 | IGHV3L*01 | 3% | TRGNNFWSGSSHYFDY | IGLV1-7*01 | 5% | QSYDSSLSVHWV |
| ITS74 | ZB42 | IGHV3K*01 | 2% | AKDLPEYCSGSGCYAAPFDY | IGKV2-3*01 | 3% | MQALQAPYS |
| ITS75 | ZB42 | IGHV4E*02 | 2% | ARHLGGLNYGGRFDF | IGKV1-22*01 | 7% | LQYSSSPFT |
| ITS76 | ZB42 | IGHV3A*01 | 4% | ARDRSIAAATYYFDY | IGLV2S6*01 | 4% | NSYAGSNTFI |
| ITS77.01 | ZB42 | IGHV4L*03 | 6% | ARVPGIWFSKYYTFDF | IGLV2S9*01 | 6% | GSYREGSTFI |
| ITS77.02 | ZB42 | IGHV4L*03 | 7% | ARVPGIWFTNYYVFDF | IGLV2S9*01 | 7% | GSYRDGSTFI |
| ZB42.1H5 | ZB42 | IGHV4A*02 | 5% | ATIVVAVSAISWFDV | IGLV1-10*01 | 2% | SAWDSSLSGVL |