Table 3. Genetic characteristics of mAbs isolated from animal 08D038, a SIVmac239-vaccinated, SIVsmE660-challenged rhesus macaque using 1JO8 SIVsmE660 V1V2-scaffolded probes.
| mAb ID | 1JO8 SIV V1V2 sort probe | Rhesus heavy V chain gene | % Divergence (nt) from germline | CDRH3 | Rhesus light chain V gene | % Divergence (nt) from germline | CDRL3 |
|---|---|---|---|---|---|---|---|
| ITS03 | E660.CR54 | IGHV1J*01 | 5% | ATEGTAAPTAF | IGKV4-3*01 | 2% | QQYYSTRLT |
| ITS06.01 | E660.CR54 | IGHV3Q*02 | 8% | ARWASRGYFDY | IGKV2S17*01 | 6% | MQVLDFPFT |
| ITS06.02 | E660.CP3C | IGHV3Q*02 | 9% | ARWASRGYFDS | IGKV2S17*01 | 6% | MQVLDFPFT |
| ITS09.01 | E660.CP3C | IGHV1J*01 | 9% | ATDPEYNCA | IGKV4-3*01 | 7% | QQYLSSPFT |
| ITS09.02 | E660.CR54 | IGHV1J*01 | 5% | ATDPEYGCT | IGKV4-3*01 | 3% | QQYYRSPFT |
| ITS09.03 | E660.CR54 | IGHV1J*01 | 11% | ATDPEYGCT | IGKV4-3*01 | 9% | QQYLNAPFT |
| ITS09.04 | E660.CR54 | IGHV1J*01 | 10% | ATDPGYGCT | IGKV4-3*01 | 7% | QQYLNAPFT |
| ITS10.01 | E660.CP3C | IGHV3AB*01 | 9% | TRGSGYNVY | IGKV3S3*01 | 12% | QQFAKWPHG |
| ITS10.02 | E660.CR54 | IGHV3AB*01 | 8% | TRGSGYNLY | IGKV3S3*01 | 10% | QQFANWPHG |
| ITS10.03 | E660.CR54 | IGHV3AB*01 | 9% | TRGSGYNVY | IGKV3S3*01 | 12% | QQFAKWPHG |
| ITS10.04 | E660.CR54 | IGHV3AB*01 | 9% | TRGSGYNIY | IGKV3S3*01 | 10% | QQFAKWPHG |
| ITS12.01 | E660.CP3C | IGHV3AB*01 | 9% | ISQEVSGSYHYFDY | IGKV2S18*01 | 4% | MQALRSPWT |
| ITS12.02 | E660.CR54 | IGHV3AB*01 | 9% | ISQEVSGSYHYFDY | IGKV2S18*01 | 4% | MQALRSPWT |
| ITS13 | E660.CR54 | IGHV3Q*02 | 13% | ARVGVAADKRYSFIDS | IGKV2S13*01 | 14% | MQSKEFPFT |
| ITS30 | E660.CP3C | IGHV3AB*01 | 13% | TRGSGYNIY | IGKV3S3*01 | 9% | QQFSSWPHDV |
| ITS34.01 | E660.CP3C | IGHV3AB*01 | 7% | ARGSGCSIY | IGKV3-4*01 | 8% | QQYSNWPHG |
| ITS34.02 | E660.CR54 | IGHV3AB*01 | 8% | ARGSGCSIY | IGKV3-4*01 | 6% | QQYSNWPHG |
| ITS34.03 | E660.CR54 | IGHV3AB*01 | 8% | ARGSGCSIY | IGKV3-4*01 | 10% | QQYSDWPHG |
| ITS37 | E660.CR54 | IGHV3AB*01 | VRGSGCNLF | IGKV3-4*01 | 10% | QQYNDWPHG | |
| 08D038.2C2 | E660.CR54 | IGHV3J*02 | 8% | TRPYYSGSYYWDY | IGKV3-2*01 | 4% | QKYSNSPYS |