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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Curr Pharmacol Rep. 2016 Feb 5;2(2):73–81. doi: 10.1007/s40495-016-0052-3

Table 1.

Dietary compounds and major molecular targets

Dietary Compound(s) Molecular Targets
Curcumin NO, COX-2, NK-kB, MAPK, PI3K/ AKT/Fox01 / BRCA-1, H2AFX and PARP-1, hsp
Resveratrol NF-κB / Wnt/β-catenin
Lycopene IGBPs/PDGF/VEGF PI3K/AKT/PKB, Ras/Raf/MAP, cyclin D, c-myc Bcl-2, Bcl-XL, ERK/AKT, NF-κB
Epigallocatechin-3-gallate Caspase activation, Bcl-2; NF-κB MAPK/TGF-B/ EGFR / JAK/STAT; PI3K/AKT, Wnt/Notch
Quercetin p53 / ras protein/ estrogen receptor/ NF-κB, EGFR/ PI3K/AKT/ MAPKs;TRPM7
Diallyl disulfide MAPKs and NF-κB/ PI3K/AKT; p53/p21 and MEK-ERK
Genistein NF-κB, VEGF, PDGF, EGF, IGF, JNK1, ERK/PI3K/AKT
Indole-3-carbinol and Sulforaphane Nrf2/ARE/ Wnt/β-Catenin