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. Author manuscript; available in PMC: 2016 Apr 11.
Published in final edited form as: J Transl Sci. 2016 Mar 5;2(2):117–124. doi: 10.15761/JTS.1000127

Figure 2.

Figure 2

Cytotoxic profiles of various antineoplastic agents against SKOV-3, OV-90 and TOV-21G cells. Panel A, cytotoxicity was measured using clonogenic assays. For the guanine O6-chloroethylating agent 90CE, cells were pretreated with 10 µM O6-benzylguanine for 2 h to abrogate activity of O6-methylguanine-DNA methyltransferase (MGMT). O6-Benzylguanine was present in the medium throughout treatment and colony propagation. Panel B, for clarification, values of LC90 (concentration giving 90% lethality) and fold resistance (degrees of resistance in OV-90 and SKOV-3 relative to TOV-21G) are tabulated.