Figure 2.

Salidroside increases locomotor activity.

Notes: (A) The climbing abilities of EAPP/BACE, EAβ₄₂, EAβ₄₂; Aβ₄₂, and Aβ_{42 E22G} transgenic flies were assessed after eclosion. Climbing deficits in these fly lines were compared with the control flies (CS). (B) The percentage of flies climbing up 8 cm in 10 seconds increased after salidroside or Aricept treatment in EAPP/BACE and EAβ lines at day 30. Mean ± SEM. *P<0.05, **P<0.01, and ***P<0.001 compared to the control group with one-way ANOVA analysis followed by Tukey’s test.

Abbreviations: APP, amyloid precursor protein; BACE, beta-secretase; CS, Canton-S; ANOVA, analysis of variance; Ctrl, control; Sal, salidroside; Aβ, amyloid-β; SEM, standard error of the mean.